Most Read Articles
01 May 2018
CoQ10 isn't as popular as vitamin C or B in our daily lives but it's time to have a closer look at this vital nutrient.
Rachel Soon, 31 Jan 2019

Despite increased availability of treatment options, hypertension and associated comorbidities remain a substantial public health concern, says an expert.

Psoriasis drug may help fight coronary plaques

10 Feb 2019

Biologic therapies for severe psoriasis appear to help reduce noncalcified coronary plaques and improve plaque morphology, a recent study has shown.

Researchers conducted a prospective observational study including 121 psoriasis patients, of whom 89 received biologic treatments (mean age 49.1±12.2 years; 56 percent male) and 32 (mean age 51.2±12.0 years; 63 percent male) were treated with other agents. Participants tended to have low cardiovascular risk (median Framingham score, 3) with moderate-to-severe skin disease (median Psoriasis Area and Severity Index [PASI], 8.6).

After a year of follow-up, patients who were treated with biologic agents showed significant improvements in the PASI score (64-percent improvement, p<0.001), as well as a significant reduction in high-sensitivity C-reactive protein levels (p<0.001). No such changes were observed in the comparison group.

Moreover, a 5-percent decrease in total coronary plaque burden was observed in participants on biologic therapy (p=0.009), an effect primarily driven by a drop in the noncalcified plaque burden (p=0.005). No improvements in fibrous burden (p=0.71) were reported, though fibro-fatty (p=0.004) and necrotic (p=0.03) burdens decreased.

In comparison, those receiving nonbiologic interventions showed no significant 1-year change in total plaque burden (p=0.22), noncalcified plaque burden (p=0.17) and fibrous burden (p=0.22). There was also an increase in fibro-fatty burden (p=0.004).

Intergroup comparisons showed that the 1-year reduction in noncalcified plaque was significantly greater in patients treated with biologic agents (p=0.03) even after adjustments for cardiovascular risk factors.

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Most Read Articles
01 May 2018
CoQ10 isn't as popular as vitamin C or B in our daily lives but it's time to have a closer look at this vital nutrient.
Rachel Soon, 31 Jan 2019

Despite increased availability of treatment options, hypertension and associated comorbidities remain a substantial public health concern, says an expert.