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14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
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21 Jan 2018
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Proton pump inhibitors implicated in cholangitis

26 Sep 2019

Use of proton pump inhibitors (PPIs) contributes to increased risk of cholangitis, a large cohort study suggests.

The study involved a nationwide representative sample of the Korean general population followed for 10 years. Researchers used treatment claims to establish PPI use, as well as hospitalization and out‐patient visit claims to identify incident cholangitis.

A total of 58,863 participants had at least one PPI prescription, and 1,834 participants developed cholangitis over 4,212,003 person‐years of follow‐up. Cox regression analysis revealed that compared with nonuse, PPI use carried a sixfold increase in the risk of incident cholangitis (hazard ratio [HR], 6.06, 95 percent CI, 4.64–7.91). This association persisted in fully adjusted models (HR, 5.75, 4.39–7.54).

The risk associated with PPI was highest during treatment and decreased gradually after discontinuation (p-trend<0.001).

The present data highlight the importance of considering cholangitis as a potential complication of PPI use, researchers said.

In a separate study, PPIs were noted to induce an elevation in gastric pH that lessens the bactericidal activity of gastric acid, allowing the passage of more bacteria through the stomach into the duodenum. The investigators postulated that the more pathogens are located in the duodenum, the higher the risk that more pathogens ascend into the bile duct, leading to cholangitis. [Aliment Pharmacol Ther 2014;39:1194-1203]

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Most Read Articles
14 Feb 2020
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
Jairia Dela Cruz, 19 Feb 2020
A diet low in fat and high in fibre seems well tolerated in patients with ulcerative colitis, not contributing to increased inflammation while significantly increasing populations of Faecalibacterium prausnitzii, according to a study presented at the 2020 Crohn's & Colitis Congress.
21 Jan 2018
The Reflux Improvement and Monitoring (TRIM) programme for the management of patients with obesity and gastroesophageal reflux disease (GERD) appears to produce improvements in patient-reported symptom severity, quality of life and weight, a study reports.
Pearl Toh, 14 Feb 2020
Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).