Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.

Proton pump inhibitors exert no effect on acute MI risk

04 Dec 2017

Proton pump inhibitors do not appear to contribute to an increase in the risk of acute myocardial infarction (MI) compared with histamine-2 receptor antagonists (H2RAs), a study has shown.

Researchers followed more than 5 million new users of prescription PPIs and H2RAs for the development of MI. Median follow-up time was 60 days for patients with commercial insurance and 96 days for those with Medicare Supplemental insurance. Kaplan-Meier methods were applied to estimate the risk of MI at 3, 12 and 36 months after treatment initiation.

Results revealed the 12-month weighted risk of MI to be low overall, with approximately 2 cases per 1,000 among patients in commercial plans and 8 per 1,000 among patients in Medicare Supplemental plans.

When the risk difference (RD) was analysed, no significant difference in MI risk was seen between patients who started PPIs vs H2RAs for the first 12 months, either in the commercial population (weighted RD per 1,000, –0.08; 95 percent CI, –0.51 to 0.36) or the Medicare Supplemental population (weighted RD per 1000, –0.45;–1.53 to 0.58).

The present data indicate that physicians and patients should not avoid starting a PPI because of concerns related to MI risk, according to researchers.

The mechanism responsible for the effect of PPIs on MI is hypothesized to involve the altered vascular reactivity, as the drugs have been reported to inhibit dimethylarginine dimethylaminohydrolase. This leads to the blockade of vascular nitric oxide synthase activity and enhanced contractivity with loss of normal relaxation. [Gastroenterology 2015;149:830–833]

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Most Read Articles
22 hours ago
There appears to be a high rate of emergency department (ED) admission for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), with patients having significant in-hospital mortality, according to data from the *AANZDEM study. Furthermore, compliance with evidence-based treatments in the ED is suboptimal.
Tristan Manalac, 5 days ago
Of the newly identified genetic loci for primary angle-closure glaucoma (PACG), two are significantly associated with primary angle-closure suspect (PACS), indicating involvement in the earlier stages of the disease, a recent Singapore study has shown.
2 days ago
Resistance training appears to confer significant benefits for inflammation and insulin pathway profiles in postmenopausal breast cancer survivors, according to a study. However, the magnitude and degree of benefit from exercise may be influenced by whether or not women gained strength and/or lost weight during exercise.
Pearl Toh, 2 days ago
Patients with inflammatory bowel disease (IBD) who had primary nonresponse to an anti-tumour necrosis factor (TNF) agent ─ or inadequate response to the initial loading doses ─ were less likely to respond to second-line biologics compared with those who had secondary loss of response (LOR) or intolerance to the primary therapy, according to a systematic review and meta-analysis presented at the Crohn's & Colitis Congress (CCC) 2018 held recently in Las Vegas, Nevada, US.