Most Read Articles
Tristan Manalac, 09 Sep 2018
Structured and remote patient management interventions are effective in reducing all-cause mortality and the number of days lost due to unplanned hospitalizations in heart failure patients, according to a recent study.
Radha Chitale, 08 Apr 2016
A trial assessing the implantable CardioFit® device designed to stimulate the parasympathetic nervous system in heart failure patients failed to meet its primary endpoints – reducing the rate of hospitalization due to heart failure or death by any cause.
27 Aug 2018
Obese men appear to have better ST-elevation myocardial infarction (STEMI) prognoses than their normal weight counterparts, regardless of metabolic syndrome status, a recent study has shown.
Stephen Padilla, 04 Sep 2018
The prevalence of individuals with hypertension is expected to rise significantly with the implementation of the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) high blood pressure guidelines, according to a study.

Proton pump inhibitors do not increase risk of ischaemic stroke

04 Apr 2018

There appears to be no significant connection between the use of proton pump inhibitors (PPIs) and risk of ischaemic stroke, a recent study has shown.

The study included 68,154 females (mean age 65±7 years) recruited from the Nurses’ Health Study, and 28,989 males (mean age 69±8 years) from the Health Professionals Follow-up Study. All participants had no previous stroke incidents. Cox proportional hazards models were created to assess the association between incident stroke risk and PPI use.

Over the 12-year follow-up, 2,599 incident stroke cases were documented, most of which were in females (2,037 vs 562). The age-adjusted models showed that PPI users were at higher risk of ischaemic stroke than nonusers (hazard ratio [HR], 1.25; 95 percent CI, 1.08–1.46).

This relationship was attenuated and lost statistical significance after multivariable adjustments for smoking status, diet quality, alcohol use, aspirin and multivitamin use, and personal history, as well as further adjustments for several indications of PPI use (HR, 1.08; 0.91–1.27).

Likewise, PPI users and nonusers were at statistically comparable risks of developing total stroke (HR, 1.11; 1.00–1.24) or haemorrhagic stroke (HR, 1.00; 0.72–1.38).

The findings showed that in age-adjusted and multivariate models, the risk of ischaemic stroke was higher in PPI users. However, after accounting for factors that may be involved in the initiation of PPI therapy, the relationship was fully attenuated.

“Taken together, these data suggest that the association of PPI use with ischemic stroke may be due to residual confounding by factors associated with the indication for PPI use,” said researchers.

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Most Read Articles
Tristan Manalac, 09 Sep 2018
Structured and remote patient management interventions are effective in reducing all-cause mortality and the number of days lost due to unplanned hospitalizations in heart failure patients, according to a recent study.
Radha Chitale, 08 Apr 2016
A trial assessing the implantable CardioFit® device designed to stimulate the parasympathetic nervous system in heart failure patients failed to meet its primary endpoints – reducing the rate of hospitalization due to heart failure or death by any cause.
27 Aug 2018
Obese men appear to have better ST-elevation myocardial infarction (STEMI) prognoses than their normal weight counterparts, regardless of metabolic syndrome status, a recent study has shown.
Stephen Padilla, 04 Sep 2018
The prevalence of individuals with hypertension is expected to rise significantly with the implementation of the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) high blood pressure guidelines, according to a study.