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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
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Proton pump inhibitor use poses increased stone risk

09 Apr 2020

Use of proton pump inhibitors (PPIs) appears to contribute to a higher risk of developing kidney stones in a dose-dependent fashion, as shown in a study. Likewise, histamine-2 receptor antagonists (H2RAs) are associated with a risk increase, suggesting the possibility of acid suppression as an underlying mechanism.

Researchers looked at 465,891 male and female patients from the Women’s Veteran’s Cohort Study. They collected data on PPI usage over time, demographics, laboratory results, comorbidities and medication usage. H2RA use was additionally identified, while levothyroxine use was used as a negative control exposure.

PPI use conferred a heightened risk of developing kidney stones in unadjusted analysis (hazard ratio [HR], 1.74, 95 percent confidence interval [CI], 1.67–1.82). This association persisted in the adjusted analysis (HR, 1.46, 95 percent CI, 1.38–1.55) and maintained in a propensity score-matched subset of PPI users and nonusers (HR, 1.25, 95 percent CI, 1.19–1.33).

Notably, the relationship between PPI and the risk of kidney stones followed a dose-dependent pattern. Each increase in 30 defined daily doses of PPI over a 3-month period was associated with an 11-percent increase in the risk of developing kidney stones (HR, 1.11, 95 percent CI, 1.09–1.14).

The risk of incident kidney stones also increased with H2RA (HR, 1.47, 95 percent CI, 1.31–1.64) but not with levothyroxine use (HR, 1.06, 95 percent CI, 0.94–1.21).

Although there was a positive association between PPIs and H2RAs with kidney stones, the effect is small and should not influence prescribing for most patients, the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.