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09 Jan 2019
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Proton pump inhibitor use does not elevate dementia risk

15 Feb 2018
Suicidal thoughts and preoccupation with death in the elderly may be due to underlying causes like depression or dementia and should raise some flags

Use of proton pump inhibitors (PPIs), even at higher cumulative levels, does not increase the risk for dementia, a recent study has shown.

The study included 3,484 elderly adults without baseline dementia (median age 74 years; 59 percent female) who were screened for dementia every 2 years. The prevalence of baseline PPI use was 30.5 percent (n=1,061).

Over a mean follow-up of 7.5±5.0 years, 827 cases of dementia were reported, resulting in an occurrence rate of 23.7 percent. Possible or probable Alzheimer’s disease was identified in 670 of these. There was no significant relationship between PPI use and the risk of dementia (p=0.66).

Cumulative use of PPI was also unrelated to dementia risk. For instance, those with 365 total standardized daily doses (TSDD; hazard ratio [HR], 0.87; 95 percent CI, 0.65–1.8) had a statistically comparable risk of dementia vs those with no PPI use.

TSDD of 1,095 (HR, 0.99; 0.75–1.30) and 1,825 (HR, 1.13; 0.82–1.56) likewise did not lead to significant changes in dementia risk. This suggested that 1, 3 and 5 years of cumulative PPI use did not increase the risk of dementia.

Levels of exposure, amount of PPI intake and duration of use were all also not significantly connected to the risk of dementia.

“Although there are other safety concerns with long-term PPI use, results from our study do not support that patients and clinicians should avoid these medications because of concern about dementia risk,” said researchers.

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Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 5 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 5 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
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