Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.

Proton beam therapy combined with intravitreal anti-VEGF safe, effective for eAMD

25 Nov 2020
A diet rich in Vitamin C helps slow down macular degeneration, according to a study, delaying the onset of cataract.

The combination of proton beam therapy (PBT) with the intravitreal administration of anti-vascular endothelial growth factor (VEGF) reduces the need for anti-VEGF reinjection in the eyes of patients with exudative age-related macular degeneration (eAMD), a recent study has shown.

There appear to be some signals for concern, however, as geographic atrophy (GA) developed in eyes receiving high radiation doses, which could negatively impact vision in the long-term.

Twenty-three eyes of newly diagnosed patients with eAMD were entered into a phase I/II prospective, sham-controlled, double-mased investigation. Receipt of 24 GyE, 16 GyE, or sham radiation was randomly assigned at 1:1:1 ratio, and all participants were given three initial monthly doses of intravitreal ranibizumab or bevacizumab.

Over 2 years of follow-up, no significant differences in best-corrected visual acuity (BCVA) was detected between the three treatment groups, though patients who received the 24-GyE dose had worse eyesight by the end of follow-up that was of borderline significance (p=0.05).

Repeat injections of anti-VEGF was performed on case-by-case basis, and was dependent on the need as assessed by monthly optical coherence tomography. Patients who received the 24-GyE PBT dose had significantly fewer injections than their sham comparators both at the 1-year (p<0.001) and 2-year (p=0.002) follow-ups.

Those who received the 16-GyE dose also had numerically fewer repeat injections than sham patients, though the difference failed to reach significance.

In terms of treatment safety, the researchers detected no significant among-group difference in terms of mean GA area and its associated rate of growth. However, patients receiving the highest radiation dose had a nonsignificantly larger mean GA size and rate of growth as compared to the sham group. This may affect long-term vision, though further investigations are needed to determine if this is indeed related to radiation or just due to the normal progression of eAMD.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.