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Proneurotensin predicts CVD in elderly population

11 May 2018
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Proneurotensin is an independent predictor of cardiovascular disease (CVD) development in both men and women in the elderly population, but it only predicts diabetes in women, according to a study.

A total of 456 first CVD events and 222 incident cases of diabetes occurred in the study. For every 1 standard deviation (SD) increase in proneurotensin, the hazard ratio (HR) was 1.10 (95 percent CI, 1.01–1.21; p=0.037), and the above vs below median HR was 1.27 (1.06–1.54; p=0.011), with similar effect sizes in both genders.

No significant association was observed between proneurotensin and incident diabetes in the entire population (p=0.52) or among men (p=0.52). However, proneurotensin predicted diabetes incidence in women, with a per 1 SD increment HR of 1.28 (1.30–1.59; p=0.025) and an above vs below median HR of 1.41 (1.10–1.80; p=0.007).

Fasting proneurotensin measurement was performed in plasma obtained from 4,804 participants (mean age 69 years) of the Malmo Preventive Project. Participants were followed up for development of CVD and diabetes for 5.4 years.

Multivariate adjusted Cox proportional hazard models were used to relate the proneurotensin to the risk of incident CVD and diabetes in all subjects and in gender-stratified analyses.

“The gut hormone neurotensin promotes fat absorption, diet-induced weight gain and liver steatosis. Its stable precursor-hormone fragment ‘proneurotensin’ predicts cardiometabolic disease in middle-aged populations, especially in women,” the investigators noted.

In a previous study, Melander and colleagues found a significant association between fasting proneurotensin and the development of diabetes, CVD, breast cancer, and total and CV mortality. [JAMA 2012;308:1469-1475]

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Most Read Articles
Stephen Padilla, 28 Nov 2017
A dietary pattern rich in fresh and dried fruits, nuts and seeds, vegetable oils, and low-fat dairy products appears to lower the incidence rate of insulin resistance, according to an Iran study.
Pearl Toh, 20 Apr 2018
The investigational oral synthetic androgen dimethandrolone undecanoate (DMAU) suppresses serum testosterone levels to near castrate levels and appears safe when taken once daily for a month, showing potential as a male contraceptive pill, according to a study.
02 Aug 2018
Men and women who regularly eat seafood appear to have higher sexual intercourse frequency (SIF) and fecundity in a large prospective cohort of couples attempting pregnancy, suggests a study.
12 Apr 2018
In the context of low-glycaemic index (GI) dietary patterns, eating pasta does not contribute to adiposity and may even reduce body weight and body mass index (BMI) compared with higher-GI dietary patterns, a recent study has found.