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Prompt anti-influenza medication shortens hospital stay in children with tracheostomy

11 Mar 2019

Early administration of anti-influenza medications in children with tracheostomy cuts the length of stay in the hospital by a day, although these children continue to receive antibiotics even after detection and treatment of their viral infections, a study has shown.

The study included 899 paediatric patients aged 30 days to 19 years who had been admitted for tracheostomy and influenza infection (median age at admission, 5 years; 56.5 percent male) and were successfully discharged.

In the cohort, 513 patients received anti-influenza medications on hospital day 0 or 1 (anti-influenza group) while the 386 did not (nonmedicated controls). Most of these patients had multiple complex chronic conditions (median, 3) and technology dependence, such as gastrostomy tube (73.6 percent).

A total of 772 patients were matched by propensity score, with 386 patients each in the anti-influenza and nonmedicated groups. The primary endpoint of length of hospital stay was shorter in the group that received anti-influenza medications (6.4 vs 7.5 days; p=0.01). Revisit rates did not differ significantly (27.5 percent vs 24.1 percent; p=0.28).

The majority of patients in both groups (>80 percent) received empirical antibiotics, and the duration of antibiotic therapy was comparable (5.0 vs 5.6 days; p=0.11).

Findings of the present study support the recommendation of prompt administration of anti-influenza medications in all children hospitalized with influenza, as well as provide insight into antibiotic prescribing behaviour regarding children with tracheostomy hospitalized with viral respiratory tract infections, researchers said.

When managing children with medical complexity, adherence to current influenza treatment guidelines in the inpatient setting is especially important given the present challenges in providing effective influenza prevention and increased risk of hospitalization, they added.  

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.