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01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
22 Feb 2021
Continuous infusion (CI) hydrocortisone therapy in patients with septic shock is not associated with a beneficial impact on mean blood glucose or influence glycaemic variability as compared to bolus dose (BD) therapy, reports a study.
Pearl Toh, 19 Mar 2021
Dupilumab effectively prevents severe asthma exacerbations and improves lung function in patients with difficult-to-treat type 2 asthma, according to a post hoc analysis of the LIBERTY ASTHMA QUEST study presented at AAAAI 2021.
Elaine Soliven, 17 Mar 2021
Treatment with an intranasal budesonide aqueous spray led to significantly reduced nasal symptoms in adults with rhinitis exposed to high levels of airborne pollution, according to a study presented at AAAAI 2021.

Prolonged opioid exposure can mess up cognition in seniors

08 Apr 2021

Persistent use of opioids for pain management in older adults may adversely affect their cognitive function, a study has found.

The analysis involved 2,222 individuals aged 65–69 years at baseline from the prospective Personality and Total Health Through Life Study in Australia. Their medication data were drawn from the Pharmaceutical Benefits Scheme.

Exposure to opioids was expressed as Total Morphine Equivalent Dose (MED). All participants underwent a neuropsychological battery assessment to examine cognition. Generalized linear models were used to estimate the association between change in cognitive function between wave 2 and wave 3 and cumulative opioid use.

Results showed that the opioids had a negative effect on cognitive function. Specifically, cumulative exposure exceeding total MED of 2,940 correlated with poorer performance in the Mini Mental State Examination (MMSE).

Compared with those who never used the drugs, individuals exposed to opioids resulting in cumulative total MED of >2,940 had poorer scores in the MMSE (model 1: β, −0.34; model 2: β, −0.35; model 3: β, −0.39; p<0.01).

Opioid use had no impact on performance in other cognitive assessments.

The findings encourage the need for alternative pain management strategies in older adults, emphasizing that the options should not adversely affect healthy ageing trajectories and cognitive health.

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Most Read Articles
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
22 Feb 2021
Continuous infusion (CI) hydrocortisone therapy in patients with septic shock is not associated with a beneficial impact on mean blood glucose or influence glycaemic variability as compared to bolus dose (BD) therapy, reports a study.
Pearl Toh, 19 Mar 2021
Dupilumab effectively prevents severe asthma exacerbations and improves lung function in patients with difficult-to-treat type 2 asthma, according to a post hoc analysis of the LIBERTY ASTHMA QUEST study presented at AAAAI 2021.
Elaine Soliven, 17 Mar 2021
Treatment with an intranasal budesonide aqueous spray led to significantly reduced nasal symptoms in adults with rhinitis exposed to high levels of airborne pollution, according to a study presented at AAAAI 2021.