Proinflammatory dietary patterns do not increase risk of psoriasis, psoriatic arthritis, atopic dermatitis
Adopting proinflammatory dietary patterns does not seem to increase the risk of psoriasis, psoriatic arthritis (PsA) or atopic dermatitis (AD) in women, reports a recent study.
The study included 85,185 women for the analysis of psoriasis and 63,443 for the evaluation of AD, in whom the Empirical Dietary Inflammatory Pattern (EDIP) score was calculated at baseline and every 4 years. Incidence rates of diseases were measured according to self-reports. Participants were enrolled from the Nurses’ Health Study II.
Over 2,014,487 person-years of follow-up, 1,425 cases of psoriasis were reported. Multivariable Cox proportional hazards analysis found no significant correlation between EDIP and psoriasis risk. For instance, those in the second (hazard ratio [HR], 0.96; 96 percent CI, 0.81–1.13) and fifth (HR, 0.97; 0.82–1.16; ptrend=0.67) quintiles of EDIP scores were not significantly more likely to develop the condition as compared with participants who had low scores.
On the other hand, PsA was diagnosed in 262 patients over a duration of 2,030,235 person-years. A similarly null trend existed between PsA risk and EDIP scores. Patients in the two top quintiles of EDIP scores (fifth: HR, 1.17; 0.77–1.76; fourth: HR, 1.13; 0.74–1.71; ptrend=0.70) did not have an increased PsA risk.
In comparison, 403 patients had been diagnosed with AD over a follow-up of 1,130,810 person-years. The fully adjusted model likewise showed no correlation between EDIP scores and AD risk (fifth quintile: HR, 0.96; 0.68–1.35; fourth quintile: HR, 1.04; 0.76–1.43; ptrend=0.99).