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01 Dec 2019
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Progression of retinal, chronic kidney disease may be influenced by similar risk factors

15 Aug 2019

It is possible that similar mechanisms mediate the progression of both retinopathy and chronic kidney disease (CKD), with a recent study showing that the association between the two progression events found on initial analysis has disappeared after adjusting for known risk factors for both diseases.

Researchers looked at 1,936 patients with CKD enrolled in the multicentre, prospective Chronic Renal Insufficiency Cohort (CRIC) Study. Of these, 1,583 attended nonmydriatic fundus photography session at baseline, and 1,025 had follow-up photography taken after a mean of 3.5 years.

Among 1,025 participants who had baseline and follow-up photographs, 930 (90.7 percent) showed no retinopathy progression, 26 (2.5 percent) showed 2-step worsening, 32 (3.1 percent) showed 3-step worsening, and 37 (3.6 percent) showed more than 3-step worsening.

End-stage renal disease (ESRD) or 50-percent decrease in estimated glomerular filtration rate (eGFR) occurred in 88 of 930 participants who had no retinopathy progression and in 18 of 95 participants with retinopathy progression.

Univariable logistic regression analysis revealed that worsening of retinopathy, as opposed to stable retinopathy, was associated with a twofold likelihood of CKD progression (odds ratio [OR], 2.24, 95 percent CI, 1.28–3.91; p=0.005). This association disappeared upon further adjustments for known risk factors for both diseases (OR, 1.62, 0.77–3.39; p=0.20).

The fact that the association became negligible in multivariable regression models implies that progression of CKD and retinopathy may be influenced by similar risk factors, the researchers pointed out. Additionally, the findings suggest substantial prevalence and progression of retinopathy in participants with CKD, supporting vigilance for monitoring eye disease in patients with CKD.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.