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Prognostic factors for large PVR following onabotulinumtoxin A injection

18 Mar 2017

Large post-void residual (PVR) volume following onabotulinumtoxin A injection in patients with overactive bladder syndrome (OAB) appear to be associated with low voiding efficiency and low 3-day daytime frequency episodes, a new study reports.

The retrospective study included 290 patients with OAB who were administered 100 U of onabotulinumtoxin A for the first time. None of the patients had urinary tract infections, neurogenic bladders or intrinsic sphincter deficiency.

Onabotulinumtoxin A was delivered via the intravesical suburethelial route. PVR, 3-day voiding diary, voided volume and uroflowmetry for Qmax were recorded every visit.

Of the 290 patients who received the injection, 133 (45.9 percent) reported large PVR (>200 mL) throughout the 6-month follow-up period. Cystomeric bladder capacity, voiding efficiency, PVR, age and daytime frequency episodes were determined as predictors of large PVR according to univariate analysis.

On the other hand, only baseline 3-day daytime frequency episodes (coefficient, 0.07; p=0.005) and baseline voiding efficiency (coefficient, 0.04; p=0.03) were the significant independent predictors according to multivariate logistic regression analysis. Median persistent large PVR was 5 months (2.5 to 5.5).

Receiver operating characteristic (ROC) curve analysis yielded an optimum cut-off value of 25 (area, 0.72; 95 percent CI, 0.60 to 0.84) for the 3-day daytime frequency episodes and 89 percent (area, 0.66; 0.60 to 0.72) for the baseline voiding efficiency.

While the study is retrospective in nature, its large sample size and use of multivariate backward stepwise logistic regression analysis make the conclusions reliable, the authors argue. The findings may thus be used as a preliminary guide for onabotulinumtoxin A injection in OAB patients.

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Most Read Articles
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Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
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