Most Read Articles
5 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
3 days ago
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
17 Aug 2019
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
6 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.

Prognostic factors for large PVR following onabotulinumtoxin A injection

18 Mar 2017

Large post-void residual (PVR) volume following onabotulinumtoxin A injection in patients with overactive bladder syndrome (OAB) appear to be associated with low voiding efficiency and low 3-day daytime frequency episodes, a new study reports.

The retrospective study included 290 patients with OAB who were administered 100 U of onabotulinumtoxin A for the first time. None of the patients had urinary tract infections, neurogenic bladders or intrinsic sphincter deficiency.

Onabotulinumtoxin A was delivered via the intravesical suburethelial route. PVR, 3-day voiding diary, voided volume and uroflowmetry for Qmax were recorded every visit.

Of the 290 patients who received the injection, 133 (45.9 percent) reported large PVR (>200 mL) throughout the 6-month follow-up period. Cystomeric bladder capacity, voiding efficiency, PVR, age and daytime frequency episodes were determined as predictors of large PVR according to univariate analysis.

On the other hand, only baseline 3-day daytime frequency episodes (coefficient, 0.07; p=0.005) and baseline voiding efficiency (coefficient, 0.04; p=0.03) were the significant independent predictors according to multivariate logistic regression analysis. Median persistent large PVR was 5 months (2.5 to 5.5).

Receiver operating characteristic (ROC) curve analysis yielded an optimum cut-off value of 25 (area, 0.72; 95 percent CI, 0.60 to 0.84) for the 3-day daytime frequency episodes and 89 percent (area, 0.66; 0.60 to 0.72) for the baseline voiding efficiency.

While the study is retrospective in nature, its large sample size and use of multivariate backward stepwise logistic regression analysis make the conclusions reliable, the authors argue. The findings may thus be used as a preliminary guide for onabotulinumtoxin A injection in OAB patients.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
5 days ago
Cardiac biomarkers are useful for identifying community-acquired pneumonia (CAP) patients with an elevated risk of early and long-term cardiovascular (CV) events, according to a study.
3 days ago
Tofogliflozin is safe and effective for elderly patients with type 2 diabetes mellitus (T2DM), regardless of insulin and oral antidiabetic drugs, reports a new Japan study.
17 Aug 2019
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
6 days ago
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.