Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Prognostic factors for large PVR following onabotulinumtoxin A injection

18 Mar 2017

Large post-void residual (PVR) volume following onabotulinumtoxin A injection in patients with overactive bladder syndrome (OAB) appear to be associated with low voiding efficiency and low 3-day daytime frequency episodes, a new study reports.

The retrospective study included 290 patients with OAB who were administered 100 U of onabotulinumtoxin A for the first time. None of the patients had urinary tract infections, neurogenic bladders or intrinsic sphincter deficiency.

Onabotulinumtoxin A was delivered via the intravesical suburethelial route. PVR, 3-day voiding diary, voided volume and uroflowmetry for Qmax were recorded every visit.

Of the 290 patients who received the injection, 133 (45.9 percent) reported large PVR (>200 mL) throughout the 6-month follow-up period. Cystomeric bladder capacity, voiding efficiency, PVR, age and daytime frequency episodes were determined as predictors of large PVR according to univariate analysis.

On the other hand, only baseline 3-day daytime frequency episodes (coefficient, 0.07; p=0.005) and baseline voiding efficiency (coefficient, 0.04; p=0.03) were the significant independent predictors according to multivariate logistic regression analysis. Median persistent large PVR was 5 months (2.5 to 5.5).

Receiver operating characteristic (ROC) curve analysis yielded an optimum cut-off value of 25 (area, 0.72; 95 percent CI, 0.60 to 0.84) for the 3-day daytime frequency episodes and 89 percent (area, 0.66; 0.60 to 0.72) for the baseline voiding efficiency.

While the study is retrospective in nature, its large sample size and use of multivariate backward stepwise logistic regression analysis make the conclusions reliable, the authors argue. The findings may thus be used as a preliminary guide for onabotulinumtoxin A injection in OAB patients.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 4 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 5 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.