Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.

Prognostic factors for large PVR following onabotulinumtoxin A injection

18 Mar 2017

Large post-void residual (PVR) volume following onabotulinumtoxin A injection in patients with overactive bladder syndrome (OAB) appear to be associated with low voiding efficiency and low 3-day daytime frequency episodes, a new study reports.

The retrospective study included 290 patients with OAB who were administered 100 U of onabotulinumtoxin A for the first time. None of the patients had urinary tract infections, neurogenic bladders or intrinsic sphincter deficiency.

Onabotulinumtoxin A was delivered via the intravesical suburethelial route. PVR, 3-day voiding diary, voided volume and uroflowmetry for Qmax were recorded every visit.

Of the 290 patients who received the injection, 133 (45.9 percent) reported large PVR (>200 mL) throughout the 6-month follow-up period. Cystomeric bladder capacity, voiding efficiency, PVR, age and daytime frequency episodes were determined as predictors of large PVR according to univariate analysis.

On the other hand, only baseline 3-day daytime frequency episodes (coefficient, 0.07; p=0.005) and baseline voiding efficiency (coefficient, 0.04; p=0.03) were the significant independent predictors according to multivariate logistic regression analysis. Median persistent large PVR was 5 months (2.5 to 5.5).

Receiver operating characteristic (ROC) curve analysis yielded an optimum cut-off value of 25 (area, 0.72; 95 percent CI, 0.60 to 0.84) for the 3-day daytime frequency episodes and 89 percent (area, 0.66; 0.60 to 0.72) for the baseline voiding efficiency.

While the study is retrospective in nature, its large sample size and use of multivariate backward stepwise logistic regression analysis make the conclusions reliable, the authors argue. The findings may thus be used as a preliminary guide for onabotulinumtoxin A injection in OAB patients.

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Most Read Articles
11 Dec 2017
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, 5 days ago
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.
01 Dec 2017
At a symposium during the 25th Congress of the Obstetrical and Gynaecological Society of Malaysia in Kuala Lumpur, Professor Susan Davis discussed the unique implications of women living decades beyond menopause, and how healthcare professionals can best manage menopausal symptoms in the short and long term.