Most Read Articles
2 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
6 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
6 days ago
Rather than the presence or type or urinary incontinence, increasing severity of urinary incontinence correlates with increased depression, anxiety and stress among treatment-seeking women with lower urinary tract symptoms (LUTS), suggests a study.
Roshini Claire Anthony, 4 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.

Procalcitonin predicts IAI after colorectal surgery

13 Jan 2018

Procalcitonin (PCT) levels are an accurate diagnostic predictor of intra-abdominal infection (IAI) following colorectal surgery, according to a recent study.

The researchers performed a meta-analysis of eight studies, corresponding to 1,629 patients, that evaluated the diagnostic value of PCT for IAI in postoperative days 3–5 in patients who underwent colorectal surgery.

Pooled data from all eight studies showed an IAI prevalence of 5.7 percent 3 days after surgery. This rose to 9.7 percent on day 4 and dropped to 6.3 percent on day 5. On day 3, PCT showed a diagnostic odds ratio (DOR) of 13.92 (95 percent CI, 5.70–34.00) and an area under the curve (AUC) of 0.83. The corresponding sensitivity and specificity at this time point was 0.68 and 0.85.

Three studies were pooled to evaluate the performance of PCT on day 4. The analysis resulted in a sensitivity of 0.81 and specificity of 0.52. The DOR and AUC values were 5.08 (1.88–13.76) and 0.79, respectively.

PCT had the highest diagnostic value for IAI 5 days after the operation, which was evaluated in three studies. The pooled analysis revealed a sensitivity and specificity of 0.78 and 0.88 percent, respectively. The DOR was at its highest value of 32.39 (15.01–69.88), while the AUC was calculated to be 0.94.

In terms of overall quality, measured using the revised Quality Assessment of Diagnostic Accuracy Studies, some studies had poorly defined criteria of the reference tests used. The applicability of two studies was also questionable because of considerable patient attrition and exclusion of emergency cases.

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Most Read Articles
2 days ago
The types of bariatric surgery differentially affect the risk of developing acute pancreatitis postoperatively, such that the risk is greater in patients who undergo vertical sleeve gastrectomy vs Roux-en-Y gastric bypass surgery, according to a study. Risk factors include younger age and presence of gallstones.
6 days ago
Elderly adults using hypoglycaemic glucose-lowering drugs, such as insulin and glinides, have an excess risk of hospitalization for serious trauma, a recent study has found.
6 days ago
Rather than the presence or type or urinary incontinence, increasing severity of urinary incontinence correlates with increased depression, anxiety and stress among treatment-seeking women with lower urinary tract symptoms (LUTS), suggests a study.
Roshini Claire Anthony, 4 days ago

Overweight or obese patients taking lorcaserin as an appetite suppressant may have the added benefit of a reduced risk of incident diabetes, according to results of the CAMELLIA-TIMI 61* trial presented at EASD 2018.