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Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
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2 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.

Probiotics offer little in terms of GI symptoms in systemic sclerosis

06 Jun 2019

Treatment with probiotics falls short of improving gastrointestinal (GI) symptoms in patients with systemic sclerosis (SSc), a study has shown.

The study randomized 73 SSc patients with a moderate–severe total score on the University of California Los Angeles Scleroderma Clinical Trials Consortium Gastrointestinal Tract 2.0 (UCLA GIT 2.0) instrument to receive a daily dose of probiotics (Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus acidophillus and Bifidobacterium lactis, 109 colony-forming units per capsule; n=37) or placebo (n=36) for 8 weeks.

After 8 weeks of treatment, the primary outcome of change in UCLA GIT 2.0 total score did not significantly differ between the two treatment groups.

However, probiotics treatment produced a significant decrease in the proportion of Th17 cells compared with placebo (p=0.003). There was no between-group difference observed in the proportion of Th1, Th2 and regulatory T cells or in the Health Assessment Questionnaire-Disability Index (HAQ-DI) score.

Although probiotics did not improve GI symptoms in SSc patients, the improvement in Th17 cell levels suggests that the treatment exerts an immunomodulatory effect on SSc, researchers pointed out.

SSc is a multisystem connective tissue disorder of unknown aetiology, and the GI tract is affected in the vast majority (90 percent) of patients. Gut involvement—with symptoms ranging from gastro-oesophageal reflux to faecal incontinence—is the leading cause of morbidity and the third most common cause of mortality in patients with SSc. [Rheumatology 2019;49:1770-1775]

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
2 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.