Most Read Articles
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.

Probiotics, synbiotics beneficial for PCOS patients

15 Apr 2020

Probiotics and synbiotics may help improve glucose control, as well as hormonal and inflammatory indices, in women with polycystic ovary syndrome (PCOS), a recent study has shown.

Accessing the databases of PubMed, Scopus, Cochrane, Google Scholar and Web of Science, researchers included eight randomized controlled trials, corresponding to nine treatment arms. Four studies used probiotics and the remaining used synbiotics. All studies were deemed to be of high quality, according to Jadad scores. A total of 540 women were included.

Probiotics and synbiotics had a significant suppressive effect on fasting blood sugar (mean difference, –2.52 mg/dL; 95 percent confidence interval [CI], –4.10 to –0.95), insulin concentration (mean difference, –2.27 µIU/mL; 95 percent CI, –3.40 to –1.14) and C-reactive protein levels (CRP; mean difference, –1.69, 95 percent CI, –3.00 to –0.38).

Testosterone was also significantly decreased (mean difference, –0.12 ng/mL; 95 percent CI, –0.17 to –0.08) as was the homeostasis model assessment-estimated insulin resistance index (HOMA-IR; mean difference, –0.69, 95 percent CI, –0.98 to –0.40).

Weight and body mass index, on the other hand, showed no significant changes as a result of probiotic or synbiotic use.

Subgroup analysis according to type of supplementation found that synbiotics significantly reduced fasting blood sugar, insulin, CRP and HOMA-IR, while probiotics decreased body weight and fasting blood sugar.

“Future studies are required to confirm the beneficial effect of probiotics and synbiotics in the treatment and management of PCOS,” said researchers.

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Most Read Articles
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.