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Probiotics, paraprobiotics supplementation improves perceived sleep health

15 Nov 2020

Supplementation with live microorganisms (probiotics) or nonviable microorganisms/microbial cell fractions (paraprobiotics) appears effective in improving perceived sleep health, measured using the Pittsburgh Sleep Quality Index (PSQI), results of a study have shown.

“Inadequate sleep (ie, duration and/or quality) is becoming increasingly recognized as a global public health issue,” the investigators said. “Interaction via the gut-brain axis suggests that modification of the gut microbial environment via supplementation with probiotics or paraprobiotics may improve sleep health.”

A systematic review and meta-analysis were conducted to examine the effect of consuming probiotics or paraprobiotics on subjective and objective sleep metrics. The investigators searched online databases from 1980 to 2019 for studies involving adults who consumed probiotics or paraprobiotics in controlled trials, during which changes in subjective and/or objective sleep parameters were evaluated.

Fourteen studies (20 trials) met the eligibility for the meta-analysis. Random effects meta-analyses revealed a significant reduction in PSQI score (ie, improved sleep quality) with probiotics or paraprobiotics supplementation relative to baseline (–0.78 points, 95 percent confidence interval, 0.395–1.166; p<0.001).

However, supplementation showed no significant effect for changes on other subjective sleep scales or objective parameters of sleep (ie, efficiency/latency), measured using polysomnography or actigraphy.

In subgroup analysis for PSQI data, the magnitude of the effect seemed greater (although not statistically significant) in healthy participants compared to those with a medical condition when treatment contained a single (rather than multiple) strain of probiotic bacteria and when treatment duration was ≥8 weeks.

“While current evidence does not support a benefit of consuming probiotics/paraprobiotics when measured by other subjective sleep scales, nor objective measures of sleep, more studies using well-controlled, within-subject experimental designs are needed,” the investigators said.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).