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Elaine Soliven, 4 days ago

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Stephen Padilla, 4 days ago
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Probiotic yogurt of no benefit in preventing antibiotic-associated diarrhoea

09 Dec 2018

Supplementation with probiotics containing the combined LA-5, BB-12 and LC-01 strains does not effectively prevent antibiotic-associated diarrhoea in hospitalized patients, a study has shown.

The study randomized 314 hospitalized patients (mean age 76 years) to receive on a daily basis 200 mL of placebo-yogurt (Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus), 200 mL of probiotic yogurt (previous plus Lactobacillus acidophilus La-5, Bifidobacterium animalis subsp. lactis Bb-12 and Lactobacillus casei subsp. casei Lc-01) or no yogurt (unblinded control) within 48 hours of initiating antibiotic therapy and up to 5 days after stopping the antibiotic.

During the 1-month follow-up, diarrhoea occurred in 23.0 percent of patients in the probiotic group vs 17.6 percent in the placebo group (absolute risk reduction, –5.35 percent; 95 percent CI, –15.4 to 4.7; p=0.30). The rate did not significantly differ in the unblinded external control and in the blinded study groups combined (20.9 percent vs 20.2 percent, respectively; p=0.91).

Duration of diarrhoea, maximum number of bowel movements or prolonged admission because of diarrhoea were similar among the groups. All-cause mortality rates were also comparable.

The findings provide no clear evidence of the benefit of using probiotics as prophylaxis for antibiotic-associated diarrhoea, researchers said.

The appeal of using probiotics stems from their accessibility, affordability and acceptable known safety profile. However, available data make it difficult to draw any solid conclusion about their role in antibiotic-associated diarrhoea. It would be reasonable to recommend probiotics in certain populations such as patients with a history or risk factors for such a condition. [World J Gastroenterol 2014;20:17788-17795]

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.