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22 Jul 2020
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Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
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Probiotic supplements beneficial for T2DM patients

2 days ago

Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.

Researchers retrieved 32 randomized controlled trials from the online databases of CENTRAL, Embase, and Medline. For eligibility, probiotics pertained to pharmaceutical formulations or dairy products administered to patients.

Pooled analysis of 21 trials showed that probiotics were able to significantly reduce total cholesterol levels In T2DM patients, resulting in a mean difference of –10.06 mg/dL (95 percent confidence interval [CI], –15,94 to –4.18; p=0.001). Heterogeneity was significant (p<0.001). Moreover, researchers saw that the effect of probiotics was significant only in those with ≤8 weeks of treatment (p=0.005); no such effect was documented for durations ≥12 weeks (p=0.105).

Researchers likewise detected statistical signals when studies were analysed according to the number of bacterial strains. Multi-strain administrations led to significant reductions in total cholesterol (mean difference, –11.70 mg/dL; 95 percent CI, –18.60 to –4.79; p=0.001), an effect that was absent in single-strain probiotics (p=0.611).

In addition, probiotics also had a significant suppressive effect on triglyceride levels (mean difference, –17.18 mg/dL; 95 percent CI, –26.17 to –8.19; p<0.001), while increasing high-density lipoproteins (mean difference, 1.62 mg/dL; 95 percent CI, 0.21–3.04; p=0.025). No significant effect was found for low-density lipoprotein levels (p=0.116).

“The practical implication of our study is that probiotic administration as a supportive intervention of type 2 diabetes could be incorporated into diabetes guidelines to beneficially modify cardiometabolic risk factors,” researchers said. “Further studies are needed to investigate the combined effects of the different antidiabetic drugs and probiotic species.”

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Most Read Articles
22 Jul 2020
A picosecond alexandrite laser (PSAL) appears to be superior to Q-switched alexandrite laser (QSAL) for the treatment of nevus of Ota, as shown by its better clinical results and fewer adverse events, according to a study.
Elvira Manzano, 6 days ago
The efficacy and cardiovascular (CV) safety of the SGLT2* inhibitor empagliflozin vs DPP-4** inhibitors and GLP-1*** receptor agonists in real-world patients were demonstrated in two interim analyses of the EMPRISE+ study presented at ADA 2020.
2 days ago
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 6 days ago
Higher levels of plasma vitamin C, total and individual carotenoid biomarkers, and their composite biomarker score appear to reduce the incidence of type 2 diabetes (T2D), according to the results of a prospective case-cohort study in eight European countries.