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Probiotic supplements beneficial for T2DM patients

01 Aug 2020

Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.

Researchers retrieved 32 randomized controlled trials from the online databases of CENTRAL, Embase, and Medline. For eligibility, probiotics pertained to pharmaceutical formulations or dairy products administered to patients.

Pooled analysis of 21 trials showed that probiotics were able to significantly reduce total cholesterol levels In T2DM patients, resulting in a mean difference of –10.06 mg/dL (95 percent confidence interval [CI], –15,94 to –4.18; p=0.001). Heterogeneity was significant (p<0.001). Moreover, researchers saw that the effect of probiotics was significant only in those with ≤8 weeks of treatment (p=0.005); no such effect was documented for durations ≥12 weeks (p=0.105).

Researchers likewise detected statistical signals when studies were analysed according to the number of bacterial strains. Multi-strain administrations led to significant reductions in total cholesterol (mean difference, –11.70 mg/dL; 95 percent CI, –18.60 to –4.79; p=0.001), an effect that was absent in single-strain probiotics (p=0.611).

In addition, probiotics also had a significant suppressive effect on triglyceride levels (mean difference, –17.18 mg/dL; 95 percent CI, –26.17 to –8.19; p<0.001), while increasing high-density lipoproteins (mean difference, 1.62 mg/dL; 95 percent CI, 0.21–3.04; p=0.025). No significant effect was found for low-density lipoprotein levels (p=0.116).

“The practical implication of our study is that probiotic administration as a supportive intervention of type 2 diabetes could be incorporated into diabetes guidelines to beneficially modify cardiometabolic risk factors,” researchers said. “Further studies are needed to investigate the combined effects of the different antidiabetic drugs and probiotic species.”

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.