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Pro-inflammatory diet may increase risk of oral cancer

13 Oct 2019

A pro-inflammatory diet, as indicated by a higher score in the Energy-adjusted Dietary Inflammatory Index (E-DII), is associated with an increased risk of oral cancer, according to a China study.

In this case-control study, the authors examined the role of the potential inflammatory effects of diet, measured using the E-DII, on oral cancer. A total of 295 oral cancer cases and 425 controls from September 2010 to June 2018 were included. Participants were from Fujian Province in China.

The E-DII was calculated based on food frequency questionnaires and adjusted by total energy intake. Unconditional logistic regression model was used to estimate the association between E-DII and the risk of oral cancer.

Participants with E-DII in the fourth quartile were shown to have a higher risk of oral cancer (odds ratio, 2.57, 95 percent CI, 1.54–4.29; p-trend=0.013) as compared with those in the lowest quartile. Analyses that used E-DII as a continuous variable revealed a 3-percent higher risk (1.00–1.06) of having oral cancer for each one-unit increase in the E-DII.

In addition, a significant interaction was observed between the E-DII and oral hygiene for oral cancer (OR for those without poor hygiene, 1.96, 0.96–4.00; OR for those with poor hygiene, 4.23, 1.83–9.81; p-interaction<0.001 for both).

“More large samples and prospective studies need to validate our results and explore the prevention strategies of oral cancer via changing dietary habits,” the authors said.

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Most Read Articles
Jairia Dela Cruz, 3 days ago
Metabolic and bariatric surgery (MBS) leads to large and sustained reductions in, and even reversal of, multiple risk factors for future joint disease in adolescents with severe obesity and musculoskeletal pain, according to data from the Teen Longitudinal Assessment of Bariatric Surgery study.
Pearl Toh, 31 Dec 2019
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23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.
Pearl Toh, 6 days ago
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