Most Read Articles
24 Sep 2019
Obese patients are exposed to greater doses of radiation during radiofrequency ablation for atrial fibrillation, a recent study has found.
01 Oct 2019
Patients with greater ischaemia who underwent positron emission tomography (PET) myocardial perfusion imaging (MPI) have better survival with early revascularization, reports a study. Exploratory analyses reveal a lower threshold than that previously reported for single-photon emission computed tomography (SPECT).
Audrey Abella, 07 Oct 2019
Individuals with left main coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) continued to show similar rates of the primary outcome (composite of death, stroke, or myocardial infarction), highlighting the potential of PCI as a CABG alternative in this patient setting, according to the final r­esults of the EXCEL* trial presented at TCT 2019.

Prior statin use ups survival after cardiac arrest

05 May 2019
Statin side effects are found to be largely related to patients’ negative expectations.

Statins, when taken before cardiac arrest, improve 1-year survival outcomes, a recent study has found.

Accessing the medical records of 142,131 adults with a nontraumatic cardiac arrest, researchers identified those who had (n=4,028; mean age, 69.5±11.8 years; 57.5 percent male) and had not (n=138,103; mean age, 68.1±17.6 years; 63.2 percent male) taken statins 30 days before the cardiac arrest event. The primary clinical outcome was 1-year survival.

Propensity-score matching was performed to reduce selection bias; the resulting groups were comparable in terms of sex, urbanization and most comorbidities. In the matched cohort, those who took statins showed significantly better survival to admission (21.1 percent vs 17.2 percent; p<0.0001) and to hospital discharge (6.1 percent vs 4.3 percent; p<0.0001).

One-year survival was also significantly better in patients who received statins 30 days before the cardiac arrest event (4.8 percent vs 3.2 percent; p<0.0001). This was confirmed by Kaplan-Meier survival analysis, which showed better survival through the 1-year observation period (log-rank p<0.0001).

Logistic regression analysis further identified prior use of statins as an important factor for higher odds of 1-year survival, which remained significant even after adjustments for other independent predictors (odds ratio [OR], 1.41; 95 percent CI, 1.16–1.71; p=0.001).

The significant survival benefit was consistent in patients who used high-potency (rosuvastatin 10 mg; n=1,150; OR, 1.42; 1.04–1.94; p=0.028) and low-potency (atorvastatin 20 mg, including all other statins; n=2,878; OR, 1.43; 1.15–1.79; p=0.002) statins.

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Most Read Articles
24 Sep 2019
Obese patients are exposed to greater doses of radiation during radiofrequency ablation for atrial fibrillation, a recent study has found.
01 Oct 2019
Patients with greater ischaemia who underwent positron emission tomography (PET) myocardial perfusion imaging (MPI) have better survival with early revascularization, reports a study. Exploratory analyses reveal a lower threshold than that previously reported for single-photon emission computed tomography (SPECT).
Audrey Abella, 07 Oct 2019
Individuals with left main coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) continued to show similar rates of the primary outcome (composite of death, stroke, or myocardial infarction), highlighting the potential of PCI as a CABG alternative in this patient setting, according to the final r­esults of the EXCEL* trial presented at TCT 2019.