Most Read Articles
Dr. Joseph Delano Fule Robles, 06 May 2019

Gilteritinib, a novel inhibitor of the tyrosine kinase FLT3, improves survival outcomes among patients with relapsed or refractory acute myeloid leukaemia (AML) with FLT3 mutations vs standard chemotherapy, according to results of the phase III ADMIRAL trial reported at the American Association for Cancer Research (AACR) Annual Meeting 2019 held in Atlanta, Georgia, US.

Roshini Claire Anthony, 30 Apr 2019

Patients with advanced small cell lung cancer (SCLC) who experience disease progression despite two or more lines of therapy could benefit from pembrolizumab in the third-line setting, according to results from the phase 1b KEYNOTE-028 and phase II KEYNOTE-158* studies presented at AACR 2019.

Pretreatment PNI, NLR predict survival in early stage hepatocellular carcinoma

02 Dec 2018

Pretreatment prognostic nutritional index (PNI) and neutrophil-to-lymphocyte ratio (NLR) predict survival in patients with early stage hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA), reports a recent study.

The study included 118 newly-diagnosed HCC patients (mean age 69.4±10.4 years; 63 percent male) undergoing RFA. Over a median follow-up of 36 months, 14 percent (n=17) died due to HCC progression, 10 percent (n=12) due to liver failure and 13 percent (n=15) due to reasons unrelated to liver failure.

The resulting overall survival (OS) rates at years 1, 3 and 5 after RFA were 90 percent, 67 percent and 52 percent, respectively.

Survival analyses showed that inflammation-based indices strongly predicted OS. For instance, participants with high NLR had shorter median OS durations than those with low NLR (cutoff, 2.5; 33 vs 38.1 months). In contrast, those with high vs low PNI had longer median OS (cutoff, 40; 38.2 vs 33.2 months).

Moreover, those with combined low NLR and high PNI had the most favourable outcomes (median OS, 38.6 months). Platelet-to-lymphocyte ratio was not a prognostic factor for survival in HCC patients after RFA.

These were confirmed in multivariate Cox proportional hazards analysis, which showed that high NLR (hazard ratio [HR], 1.94; 95 percent CI, 1.05–3.59; p=0.034) and low PNI (HR, 0.38; 0.20–0.72; p=0.003) were significant and independent factors for OS.

Other such factors were a history of end-stage renal disease (HR, 3.60; 1.48–8.76; p=0.005) and elevated α-foetoprotein levels (200 ng/mL; HR, 4.61; 1.75–12.13; p=0.002).

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Most Read Articles
Dr. Joseph Delano Fule Robles, 06 May 2019

Gilteritinib, a novel inhibitor of the tyrosine kinase FLT3, improves survival outcomes among patients with relapsed or refractory acute myeloid leukaemia (AML) with FLT3 mutations vs standard chemotherapy, according to results of the phase III ADMIRAL trial reported at the American Association for Cancer Research (AACR) Annual Meeting 2019 held in Atlanta, Georgia, US.

Roshini Claire Anthony, 30 Apr 2019

Patients with advanced small cell lung cancer (SCLC) who experience disease progression despite two or more lines of therapy could benefit from pembrolizumab in the third-line setting, according to results from the phase 1b KEYNOTE-028 and phase II KEYNOTE-158* studies presented at AACR 2019.