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The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).

Preterm birth may correlate weakly with risk of research-identified ASD

17 May 2020

Research-identified autism spectrum disorder (ASD-R) appears to be more common in preterm babies, though this relationship is modified by various infant and maternal factors, a recent study has found.

Researchers performed a population-based cohort study on 7,876 children, of whom 8.6 percent were born preterm, before 37 weeks of gestation. ASD-R was identified epidemiologically, through medical and school records reviewed before 21 years of age.

Over the study period, 266 participants met the criteria for ASD-R, which developed by the median age of 6.5 years. The cumulative incidence rates of ASD-R at 5, 10, 15 and 21 years of age were 1.1 percent, 2.8 percent, 3.5 percent and 3.8 percent, respectively.

Relative to their term counterparts, children who were born preterm were significantly more likely to develop ASD-R (hazard ratio [HR], 1.64, 95 percent confidence interval [CI], 1.12–2.41).

Further stratification according to gestational age showed that CIs were wider for children born earlier: extremely preterm (HR, 2.62, 95 percent CI, 0.65–10.57) and very preterm (HR, 1.68, 95 percent CI, 0.54–5.29). Significance was only achieved in infants who were moderate-to-late preterm (HR, 1.60, 95 percent CI, 1.06–2.40).

Controlling for maternal and neonatal factors in multivariate analysis attenuated the overall correlation between preterm birth and ASD-R risk (HR, 1.42, 95 percent CI, 0.95–2.11). This was driven by the weakening of the effect of moderate-to-late preterm birth (HR, 1.42, 95 percent CI, 0.93–2.15). Extreme and very preterm birth remained nonsignificant.

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Most Read Articles
4 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 3 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
Yesterday
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.
21 May 2020
At the 13th Annual Scientific Meeting of the Malaysian Osteoporosis Society (MOS), Dr Chan Siew Pheng discussed the role of alfacalcidol (One-Alpha®) in the treatment of osteoporosis (OP) and presented several patient profiles where alfacalcidol exhibited efficacy in increasing bone mineral density (BMD).