Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.

Preoperative atrial fibrillation ups hyperfibrinolysis risk in cardiopulmonary bypass

26 Nov 2019

Atrial fibrillation before cardiopulmonary bypass appears to increase the likelihood of postoperative hyperfibrinolysis in patients with rheumatic valvular heart disease, a recent study has shown.

The study included 203 rheumatic valvular heart disease patients, of whom 78 (mean age, 54.2±8.6 years; 29.5 percent male) had hyperfibrinolysis after bypass while 125 (mean age, 54.4±8.5 years; 29.6 percent male) did not. Those who required reoperation, emergency operation, or who had renal or liver dysfunction were ineligible for analysis.

Preoperative atrial fibrillation was significantly more common among those who developed postoperative hyperfibrinolysis (92.3 percent vs 55.2 percent; p<0.01). Operative factors were comparable between groups.

After bypass, reaction time was significantly decreased in the hyperfibrinolysis group, both relative to baseline (5.9±1.2 to 5.3±1.4 minutes; p<0.05) and to the nonhyperfibrinolysis comparators (5.3±1.4 vs 5.9±1.6 minutes; p=0.011).

On the other hand, postoperative daily drainage (655.3±131.5 vs 535.4±161.4 mL; p<0.01) and the transfusion of both red blood cells (5.9±2.2 vs 4.7±2.8 units; p<0.01) and fresh frozen plasma (621.8±220.2 vs 455.2±208.5 mL; p<0.01) were all significantly greater in patients who developed postbypass hyperfibrinolysis.

Logistic regression analysis confirmed that the presence of preoperative atrial fibrillation significantly increased the risk of developing hyperfibrinolysis after bypass (odds ratio, 19.691, 95 percent confidence intervals [CI], 6.849–56.612; p<0.05).

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
4 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.