Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Prenatal dexamethasone use may affect virilization

25 Dec 2019

In neonates at risk of congenital adrenal hyperplasia, prenatal dexamethasone (DEX) exposure appears to reduce virilization but exerts no effect on physical outcomes, cognitive functions, behavioural problems and temperament, according to the results of a meta-analysis.

Researchers searched multiple online databases for studies of prenatal DEX treatment that met the following criteria: population involved pregnant women and their offspring; cohort or case-control design; outcomes included virilization, newborn physical outcomes and other long-term effects.

Pooled data revealed a significant reduction in virilization in the DEX‐treated group (weighted mean difference [WMD], −2.39, 95 percent confidence interval [CI], −3.31 to –1.47). On the other hand, there were no significant differences observed in newborn physical outcomes for birth weight (WMD, 0.09, 95 percent CI, −0.09 to 0.27) and birth length (WMD, 0.27, 95 percent CI, −0.68 to 1.21).

Likewise, prenatal DEX treatment had no effect on cognitive functions, particularly in the domains of psychometric intelligence (standardized mean difference [SMD], 0.05, 95 percent CI, −0.74 to 0.83), verbal memory (SMD, −0.17, 95 percent CI, −0.58 to 0.23), visual memory (SMD, 0.10, 95 percent CI, −0.14 to 0.34), learning (SMD, −0.02, 95 percent CI, −0.27 to 0.22) and verbal processing (SMD, −0.38, 95 percent CI, −0.93 to 0.17).

Finally, behavioural problems and temperament were similar in the DEX-treated and untreated patients. There were no significant differences in the domains of internalizing problems (SMD, 0.16, 95 percent CI, −0.49 to 0.81), externalizing problems (SMD, 0.07, 95 percent CI, −0.30 to 0.43) and total problems (SMD, 0.14, 95 percent CI, −0.23, 0.51), as well as in the domains of emotionality (SMD, 0.13, 95 percent CI, −0.79 to 1.05), activity (SMD, 0.04, 95 percent CI, −0.32 to 0.39), shyness (SMD, 0.25, 95 percent CI, −0.70 to 1.20) and sociability (SMD, −0.23, 95 percent CI, −0.90 to 0.44).

The researchers, however, advised careful interpretation of the results due to the presence of limitations. They pointed out that prenatal treatment should be optimized through a multidisciplinary national strategy.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.