Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Pregnant women who follow recommended fat, fibre intake have richer gut microbiota

14 Oct 2017

In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.

Faecal samples were collected from 100 overweight or obese women in early pregnancy and were then used for DNA extraction. Dietary intake was recorded in food diaries a week before the study visit. Fasting blood samples were collected and used to assess GlycA and lipidomics.

Results showed that intakes of total fibre, soluble fibre and nonsoluble fibres were consistently and positively associated with the diversity and richness of the gut microbiota. In contrast, intake of fat and the different fat types was negatively associated with diversity and richness.

Of all the dietary nutrients, fibre and fat intake showed the most powerful correlations, with fibre being associated with an unknown family under the order Clostridiales and with the family Barnsiellaceae under the phylum Bacteroidetes. Fat intake was negatively correlated with Barnsiellaceae abundance.

Participants were then grouped into three according to adherence to the reference dietary intake: the low-fibre/moderate-fat group (n=57), the high-fibre/moderate-fat group (n=18) and the low-fibre/high-fat group (n=13).

After adjustments, women in the high-fibre/moderate-fat group had a significantly lower relative abundance of the Bacteroidaceae family compared with the low-fibre/high-fat group (25.6 vs 42.4 percent; p=0.001) and the low-fibre/moderate-fat group (25.6 vs 33.2 percent; p=0.002).

The Bacteroides genus was also likewise significantly lower in the high-fibre/moderate fat group than in the low-fibre//moderate fat and low-fibre/high-fat groups.

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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

20 Jul 2017
Nutrition and Behaviour Modification for Picky Eaters (NBMPE) is a management plan for children with mild picky eating habits. An NBMPE Expert Programme was recently conducted by three of the expert panelists in Kuala Lumpur, which saw the participation of more than 30 paediatricians from across the country. The highlights from the event are summarized here.
Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.