Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.

Pregnancy-related acute kidney injury prevalent in women with pre-eclampsia

15 Oct 2019

Women with pre-eclampsia commonly have acute kidney injury (AKI), which is associated with higher rates of maternal and perinatal mortality, a study reports.

The study followed a total of 1,547 women admitted with pre-eclampsia who presented with maximum creatinine concentration of ≥90 μmol/L during admission in South Africa. Of these, 237 patients (15.3 percent) met the AKI criteria: 107 (6.9 percent) had stage 1 disease, 67 (4.3 percent) had stage 2 disease and 63 (4.1 percent) had stage 3 disease.

Women with vs without AKI were at greater risk of maternal death (relative risk, 4.3, 95 percent CI, 1.6–11.4) and stillbirth (relative risk, 2.2, 1.8–2.8). Additionally, perinatal mortality was high in women with AKI (89 of 240; 37.1 percent).

Hypertension in a previous pregnancy emerged as the strongest predictor of AKI stage 2 or 3 (odds ratio, 2.24, 1.21–4.17). Renal recovery rate decreased with increasing AKI stage. By discharge, renal function did not return to baseline in about a third of the surviving women (76 of 230; 33.0 percent), approximately half of whom (39 of 76; 51.3 percent) did not have further creatinine testing postdischarge.

Researchers highlighted a need for additional investigation to determine the short- and long-term outcomes of pregnancy-related AKI and whether this varies according to underlying pathogenesis. They encouraged clinicians to follow-up women with AKI whose renal function did not return to baseline at discharge.

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.