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Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

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Pregabalin shows promise for premature ejaculation

04 Mar 2020

At 150-mg doses, oral pregabalin appears to be effective for premature ejaculation (PE), increasing intravaginal ejaculation latency time (IELT), a recent study has found.

Researchers randomly assigned PE patients to receive 150-mg pregabalin (n=39; mean age, 31.7±7.09 years), 75-mg pregabalin (n=39; mean age, 32.1±6.3 years) or placebo (n=38; mean age, 30.9±7 years). Medications were taken 1–2 hours before sexual intercourse, and a stopwatch was used to measure IELT. The trial lasted for 2 weeks.

In those who received the higher dose of pregabalin, mean IELT increased from 38.7±15.2 seconds at baseline to 84.4±50.7 seconds after 2 weeks. The changes were also positive in both the 75-mg pregabalin (43.7±12.7 to 48.4±20.3 seconds) and placebo (43.1±13.4 to 44.7±14.8 seconds) groups, though to a much lesser degree. The corresponding mean percent change values were 145.2±143.3 percent, 13.7±55.2 percent and 4.2±19.5 percent, respectively.

The improvement elicited by the 150-mg dose was significantly greater than in both comparator groups. At baseline, IELT was comparable across treatment groups.

In terms of patient experience, 82 percent of men treated with 150 mg pregabalin benefited from the treatment. One patient achieved a 5-minute IELT, representing a 6-fold increase from baseline values. Two other patients had IELTs of 5 minutes. Age was not a modifying factor for IELT improvements.

These benefits came with a slightly heavier burden of safety concerns. The prevalence of adverse events in the 150-mg group was 20.5 percent, as opposed to only 12.8 percent and 2.6 percent in the 75-mg and placebo groups, respectively. However, all side effects were only mild or moderate in severity and did not lead to treatment discontinuations.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

5 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.