Most Read Articles
02 Apr 2019
Using preventive zinc and micronutrient powder supplementation does not appear to improve growth in children, a recent study has found.
Roshini Claire Anthony, 28 Sep 2020

A 4-week course of amoxicillin-clavulanate in children with protracted bacterial bronchitis (PBB) does not improve cough resolution rates compared with a 2-week course, according to a study from Australia. However, the longer course may significantly extend time to first cough exacerbation.

Prednisolone ups avascular nephrosis risk in kids with SLE

29 Sep 2020

High daily doses of prednisolone may put children with systemic lupus erythematosus (SLE) at significant risk of avascular necrosis (AVN), reports a recent study.

Drawing from Taiwan’s National Health Insurance Research Database, the researchers identified 1,472 children (mean age at diagnosis, 15.5±3.3 years; 86.1 percent girls) who had been diagnosed with SLE between 2005 and 2013. The primary outcome was the development of AVN, assessed with respect to medications taken.

Over an average follow-up duration of 4.6±2.5 years, 39 patients (37 girls and two boys) developed AVN, yielding an incidence rate of 2.6 percent. Almost all patients (92.7 percent; n=1,364) were on disease-modifying antirheumatic drugs (DMARDs), of which hydroxychloroquine was most common.

AVN patients saw a significantly shorter cumulative duration of hydroxychloroquine exposure (544.2±580.1 vs 804.1±727.2 days; p=0.009), although cyclophosphamides were more frequently used in this subgroup (46.2 percent vs 28.3 percent; p=0.015). Majority of the patients (95.5 percent; n=1,406) were prescribed systemic corticosteroids.

Multivariate Cox proportional hazards analysis showed that a higher daily dose of prednisolone, between 7.5 and 30 mg, was associated with a significantly elevated risk of developing AVN (hazard ratio [HR], 7.435, 95 percent confidence interval [CI], 2.882–19.178; p<0.001). This effect was even stronger for patients who were taking >30 mg of prednisolone per day (HR, 9.366, 95 percent CI, 2.225–39.418; p=0.002). Both risk estimates were in comparison to children on ≤75-mg/day of the medication.

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Most Read Articles
02 Apr 2019
Using preventive zinc and micronutrient powder supplementation does not appear to improve growth in children, a recent study has found.
Roshini Claire Anthony, 28 Sep 2020

A 4-week course of amoxicillin-clavulanate in children with protracted bacterial bronchitis (PBB) does not improve cough resolution rates compared with a 2-week course, according to a study from Australia. However, the longer course may significantly extend time to first cough exacerbation.