Most Read Articles
Elaine Soliven, 5 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.

Predictors of new-onset diabetes mellitus after kidney transplant

03 Jul 2020
Hospital Authority is set to introduce a pair exchange scheme for kidney transplants by the second half of 2018.

New-onset diabetes mellitus is relatively common after kidney transplantation, a new meta-analysis has found. Risk factors include older age, body mass index (BMI), family history, and some comorbidities.

Accessing the databases of PubMed, Web of Science, Embase, and the Cochrane library, researchers were able to retrieve 24 case-control studies eligible for inclusion into the meta-analysis. This corresponded to 6,127 kidney transplant patients, of whom 1,598 developed new-onset diabetes mellitus after the procedure.

Pooled analysis of 17 studies showed that, after the heterogeneity test (p<0.00001), age was a significant risk factor for the development of new-onset diabetes mellitus after kidney transplant (mean difference [MD], 6.05, 95 percent confidence interval [CI], 4.33–7.78; p<0.00001). Sex, on the other hand, was not a significant correlate of the outcome (odds ratio [OR], 1.00, 95 percent CI, 0.88–1.13; p=0.97).

Other significant risk factors included polycystic kidney disease (OR, 1.69, 95 percent CI, 1.22–2.34; p=0.002), a family history of diabetes mellitus (OR, 3.14, 95 percent CI, 1.87–5.27; p<0.0001), high BMI (MD, 1.82, 95 percent CI, 1.35–2.30; p<0.00001), and acute rejection (OR, 1.97, 95 percent CI, 1.61–2.41; p<0.00001).

Similarly, the use of tacrolimus (OR, 1.20, 95 percent CI, 1.02–1.41; p=0.03) emerged as a significant risk factor, while other medications, such as sirolimus, cyclosporin A, and steroids, were not. Infections with hepatitis B (OR, 3.53, 95 percent CI, 1.12–11.13; p=0.03) and C (OR, 1.51, 95 percent CI, 1.01–2.24; p=0.04) were also significant correlated of new-onset diabetes mellitus.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elaine Soliven, 5 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 5 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 4 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.