Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting. 

Prediagnosis metformin use improves survival in elderly diabetic HCC patients

25 Apr 2020

Prediagnosis use of metformin dose ≤1,500 mg/d results in longer overall survival among elderly diabetic patients with hepatocellular carcinoma (HCC), according to a study.

The investigators analysed data on 2,499 elderly diabetic HCC patients obtained from the SEER-Medicare programme (2009 to 2013) to examine the effect of prediagnosis and postdiagnosis use of statins and metformin on overall survival in this population. They categorized patients based on use of statins only, metformin only, both or neither (reference for all comparisons).

Further categorization was performed according to the following: (1) metformin dose: ≤1,500 or >1,500 mg/d; (2) statins functional form: hydrophilic (pravastatin and rosuvastatin) or lipophilic (atorvastatin, fluvastatin, lovastatin and simvastatin); (3) statins potency: high (atorvastatin, rosuvastatin and simvastatin) or low (fluvastatin, lovastatin and pravastatin); and (4) individual statins type.

Cox proportional hazard models were generated to calculate for multivariable-adjusted hazard ratios (HR) and 95 percent confidence intervals (CIs).

Prediagnosis use of metformin dose ≤1,500 mg/d led to a reduced risk of death following HCC diagnosis in patients with type 2 diabetes mellitus (HR, 0.72, 95 percent CI, 0.58–0.91), adjusting for postdiagnosis metformin dose, diabetes severity, Charlson comorbidity index, tumour characteristics and other relevant factors.

On the other hand, prediagnosis metformin dose >1,500 mg/d or postdiagnosis metformin use was not associated with a lower mortality risk. There was also no association seen for either prediagnosis or postdiagnosis use of statins.

“Statins and metformin have received considerable interest as potential chemopreventive agents against HCC development in individuals with type 2 diabetes mellitus,” the investigators noted.

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Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting.