Prediabetes linked to impaired sexual functioning in men
Prediabetes is likely to impair sexual functioning in young men, with the risk high in the presence of impairment of both fasting glucose and glucose tolerance, a study reports. Furthermore, sexual dysfunction is accompanied by mild depressive symptoms.
The study included four age- and weight-matched groups of apparently healthy men (25–50 years old), as follows: those with isolated impaired fasting glucose (IFG; n=16), those with isolated impaired glucose tolerance (IGT; n=17), those with both IFG and IGT (n=16), and controls with normal glucose tolerance (n=18). All men completed questionnaires that assessed sexual functioning (IIEF-15) and the presence and severity of depressive symptoms (BDI-II).
Fasting plasma glucose was higher in the IFG and IFG+IGT groups vs the IGT and control groups, whereas 2-h postchallenge plasma glucose was higher in the IGT and IFG+IGT groups vs the IFG and control groups. Furthermore, the homeostatic model for insulin resistance and triglycerides were higher, while HDL cholesterol was lower in the three prediabetic groups than in the control group.
Compared with controls, men in the IFG+IGT group achieved lower domain scores for erectile function, sexual desire and overall satisfaction, as well as the higher overall BDI-II score. Meanwhile, those with isolated IGT or IFG had lower domain score only for sexual desire.
There were correlations found between domain score for erectile function and the BDI-II score, and between scores for erectile function and sexual desire and degree of insulin resistance.
Given the small number of participants, the present data should be considered as pilot and confirmed in large clinical trials, researchers said.