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Prediabetes, diabetes not associated with increased risk of gastric adenocarcinoma

12 May 2019

Prediabetes or diabetes does not appear to increase the risk of gastric adenocarcinoma, according to a recent study.

No increased risk of gastric adenocarcinoma was identified among participants with prediabetes (hazard ratio [HR], 1.07; 95 percent CI, 0.79–1.44), diabetes (HR, 0.77; 0.46–1.29) or any of these exposures (HR, 0.96; 0.73–1.27) compared with normoglycaemic individuals.

Furthermore, stratified analyses or analyses separating cardia and noncardia gastric adenocarcinoma showed no associations between prediabetes or diabetes and the risk of gastric adenocarcinoma.

In contrast, a previous meta-analysis of prospective cohort studies found an association between prediabetes and an increased risk of cancer, particularly liver, endometrial and stomach/colorectal cancer. [Diabetologia 2014;57:2261-2269]

Another study reported the association of diabetes and prediabetes with an increased risk of cancer mortality, especially death from liver cancer. Additionally, death from all cancers showed a linear rise with increasing glucose concentrations. [Diabetologia 2010;53:1867-1876]

The present study cohort included 111,198 participants in the Northern Swedish Health and Disease Study, who were followed from November 1985 to April 1987. Oral glucose tolerance tests and self-report were used to assess the exposure to prediabetes or diabetes.

The authors identified the incidence of gastric adenocarcinoma from the Swedish Cancer Registry. They used multivariable Cox regression to analyse the associations between prediabetes or diabetes and the risk of gastric adenocarcinoma, with adjustments for sex, age, calendar year, body mass index, tobacco smoking and education level.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
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Consumption of whole almonds as snacks not only reduces low-density lipoprotein cholesterol (LDL-C) but also significantly improves endothelial function in adults with above-average risk of cardiovascular disease (CVD), according to the results of a trial.
Pearl Toh, 3 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
27 May 2020
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