Most Read Articles
2 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

2 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
6 days ago
Empagliflozin treatment in patients with type 2 diabetes mellitus exerts beneficial effects on cardiovascular (CV) risk factors, including blood pressure and uric acid, according to a systematic review and meta-analysis.
Roshini Claire Anthony, 6 days ago

A 10 or 20 mg/kg daily dose of cannabidiol could almost halve the risk of seizures in children with Dravet syndrome, according to the phase III GWPCARE2* study presented at the American Academy of Neurology annual meeting (AAN 2019).

Prediabetes, diabetes not associated with increased risk of gastric adenocarcinoma

12 May 2019

Prediabetes or diabetes does not appear to increase the risk of gastric adenocarcinoma, according to a recent study.

No increased risk of gastric adenocarcinoma was identified among participants with prediabetes (hazard ratio [HR], 1.07; 95 percent CI, 0.79–1.44), diabetes (HR, 0.77; 0.46–1.29) or any of these exposures (HR, 0.96; 0.73–1.27) compared with normoglycaemic individuals.

Furthermore, stratified analyses or analyses separating cardia and noncardia gastric adenocarcinoma showed no associations between prediabetes or diabetes and the risk of gastric adenocarcinoma.

In contrast, a previous meta-analysis of prospective cohort studies found an association between prediabetes and an increased risk of cancer, particularly liver, endometrial and stomach/colorectal cancer. [Diabetologia 2014;57:2261-2269]

Another study reported the association of diabetes and prediabetes with an increased risk of cancer mortality, especially death from liver cancer. Additionally, death from all cancers showed a linear rise with increasing glucose concentrations. [Diabetologia 2010;53:1867-1876]

The present study cohort included 111,198 participants in the Northern Swedish Health and Disease Study, who were followed from November 1985 to April 1987. Oral glucose tolerance tests and self-report were used to assess the exposure to prediabetes or diabetes.

The authors identified the incidence of gastric adenocarcinoma from the Swedish Cancer Registry. They used multivariable Cox regression to analyse the associations between prediabetes or diabetes and the risk of gastric adenocarcinoma, with adjustments for sex, age, calendar year, body mass index, tobacco smoking and education level.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
2 days ago

Dr Michael Lim, a senior consultant at the Paediatric Pulmonary and Sleep Division, National University Hospital, Singapore, speaks to Roshini Claire Anthony on the rare disease that is cystic fibrosis.

2 days ago
It appears that long-term consumption of fish and omega-3 fatty acid does not influence the risk of incident hypertension in middle-aged and older men, suggests a US study.
6 days ago
Empagliflozin treatment in patients with type 2 diabetes mellitus exerts beneficial effects on cardiovascular (CV) risk factors, including blood pressure and uric acid, according to a systematic review and meta-analysis.
Roshini Claire Anthony, 6 days ago

A 10 or 20 mg/kg daily dose of cannabidiol could almost halve the risk of seizures in children with Dravet syndrome, according to the phase III GWPCARE2* study presented at the American Academy of Neurology annual meeting (AAN 2019).