Most Read Articles
Pearl Toh, 5 days ago
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Elaine Soliven, 6 days ago

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elvira Manzano, 12 Oct 2020
Taking regular hot baths may have a positive impact on glycaemia, blood pressure (BP), and body weight among Japanese patients with type 2 diabetes(T2D), according to a real-world study touted as the first to analyse the effect of heat therapy in T2D.

Preconception levothyroxine does not improve cognitive outcomes in children

01 Oct 2020

Preconception treatment with levothyroxine fails to bring significantly better cognitive outcomes in children up to age 2 years compared with treatment initiated at 8–14 weeks of gestation, a study has found.

The authors performed this prospective, single-centre cohort study at a tertiary-care hospital to assess children’s cognitive function and ascertain the impact of preconception maternal hypothyroidism treatment on foetal neurodevelopment.

Overall, 466 women were assigned to either before conception (BC; n=187) or after conception (AC; n=279; 8–14 gestational weeks) groups by time point of hypothyroidism diagnosis and treatment. Levothyroxine therapy was adjusted based on the results of a monthly thyroid function test.

Neurocognitive development of children at age 6, 12, and 24 months was evaluated using the Gesell Development Diagnosis Scale (GDDS; Chinese version), with total score as the primary outcome.

Both BC and AC groups were similar at baseline antenatal visit, except for a higher proportion of thyroid peroxidase (TPO) antibody-positive participants in the former (p<0.001).

The GDDA neurodevelopmental assessment did not show any significant differences between groups at age 6, 12, and 24 months (p>0.05). However, there were slightly lower motor ability (p=0.009) and total (p=0.026) scores at 12 months and adaptability at 24 months (p=0.037) in the BC group.

On subgroup analysis for subclinical hypothyroidism, differences for motor ability (p<0.001) and total score (p=0.026) persisted with no significant differences in pregnancy and neonatal outcomes by severity and TPO status (p>0.05).

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Most Read Articles
Pearl Toh, 5 days ago
Cycling was associated with reduced risk for both all-cause and cardiovascular (CV) mortality in people with diabetes, according to a study presented at EASD 2020 Meeting — suggesting that cycling could be encouraged as an activity to prevent deaths in this population who are known to have a higher mortality risk than the general public.
Elaine Soliven, 6 days ago

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elvira Manzano, 12 Oct 2020
Taking regular hot baths may have a positive impact on glycaemia, blood pressure (BP), and body weight among Japanese patients with type 2 diabetes(T2D), according to a real-world study touted as the first to analyse the effect of heat therapy in T2D.