Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 5 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 3 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

Prebiotics help mitigate inflammatory state in overweight, obese people

06 Oct 2019

Supplementation with prebiotics appears to confer benefits for the inflammatory state in individuals who are overweight or obese, with the results of a meta-analysis showing that it may help regulate blood concentrations of ghrelin and C-reactive protein (CRP).

Researchers performed a systematic review of clinical trials evaluating the effect of prebiotic or synbiotic supplementation on biochemical outcomes (adrenocorticotropic hormone, cortisol, leptin, ghrelin, thyroid-stimulating hormone [TSH], parathyroid hormone [PTH], vitamin D, brain-derived neurotrophic factor [BDNF] and CRP) in adults with a body mass index (BMI) of 25 kg/m2.

The meta-analysis included 13 trials, one of which used synbiotics in the intervention while the remaining 12 used prebiotics. The latter used inulin-type fructans (fructo-oligosaccharides, inulin and oligofructose) or galacto-oligosaccharides, with doses ranging from 2.03 to 24 g/d and durations ranging between an acute dose and 90 days of supplementation.

Pooled data showed that supplementation with inulin-type fructans reduced serum concentrations of ghrelin (−37.17 pg/mL, 95 percent CI, −69.62 to −4.73; p=0.025) and CRP (standardized mean difference, −0.31, −0.58 to −0.04; p=0.027).

The researchers said that further studies should be conducted to examine the possible therapeutic effect of prebiotics on outcomes associated with depression and anxiety.

Obesity share similar risk factors with emotional disorders, such as depression and anxiety. These factors include stress, low physical activity, poor nutrition and chronic inflammation. Inflammation status—which has been associated with alterations in serum concentrations of insulin, leptin, ghrelin and cortisol, and with vitamin deficiency—may be of particular importance, as it has been reported to carry an increased risk of cardiovascular diseases, cancer, dementia and diabetes, among others. [Neurosignals 2017;25:54-73]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 5 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
4 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 3 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.