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Pre-eclampsia linked to preclinical atherosclerosis in T1D women

19 Jan 2020

Previous pre-eclampsia (PE) is associated with increased preclinical carotid atherosclerosis in women with type 1 diabetes (T1D), reports a study.

One hundred twelve women without cardiovascular (CV) disease and who had their last pregnancy 5 years before were enrolled and categorized as follows: (1) T1D and previous PE (T1D+/PE+; n=28); (2) T1D without PE (T1D+/PE; n=28); (3) previous PE without T1D (T1D/PE+; n=28); and (4) controls (without T1D or PE; T1D/PE; n=28).

The authors matched the groups by age, several CV risk factors, and diabetes duration and retinopathy (in women with T1D). Standardized ultrasonography protocol was used to assess carotid intima-media thickness (IMT) and the presence of plaque (IMT 1.5 mm).

Of the participants (mean age, 44.9±7.8 years), 21.4 percent were active smokers and 14.3 percent had hypertension). Women in T1D groups (T1D+/PE+ and T1D+/PE) were more likely to present with hypertension (23.2 percent vs 5.4 percent; p<0.01) and be on statin treatment (37.5 percent vs 8.9; p<0.01), without differences in other CV risk factors. About a fifth (20.5 percent) of the participants had carotid plaques.

Multivariate models adjusted for age, statins and CV risk factors showed a similar impact of both T1D (odds ratio [OR], 5.45, 95 percent confidence interval [CI], 1.36–21.9) and PE (OR, 4.24, 95 percent CI, 1.04–17.3) on the presence of plaque.

An additive effect was observed when T1D and PE were combined, both in common carotid-IMT (T1D+/PE or T1D/PE+: β, 0.198; T1D+/PE+: β, 0.297) and in the presence of plaque (OR, 8.53, 95 percent CI, 1.07–68.2 and OR, 28.1, 95 percent CI, 2.67–296.4, respectively).

“Further studies are needed to ascertain its usefulness for stratifying risk in T1D women,” according to the authors.

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Most Read Articles
4 days ago
A recent study has shown no improvement in the rate of blood pressure (BP) control despite an increase in the prevalence of antihypertensive medication use.
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Jairia Dela Cruz, 25 Nov 2019
Use of the PCSK9* inhibitor alirocumab in acute coronary syndrome (ACS) patients on a background of high-intensity statin treatment delivers reductions in total hospitalizations and death with corresponding gains in days alive and out of hospital (DAOH), according to the results of prespecified and posthoc analyses of the ODYSSEY OUTCOMES** trial presented at the American Heart Association (AHA) 2019 Scientific Sessions.
09 Feb 2020
Short-term, reading-to-reading ambulatory blood pressure (BP) variability appears to be associated with total and cardiovascular mortality among individuals with hypertension, according to data from the Spanish ABPM Registry.