Most Read Articles
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Stephen Padilla, 11 Feb 2020
The inclusion of two proanthocyanidin (PA)-rich apples into normal diets improves cardiovascular disease (CVD) risk factors by reducing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and intercellular cell adhesion molecule-1 (ICAM-1), as well as increasing microvascular vasodilation, in individuals with mildly elevated serum cholesterol concentrations, a recent study has shown.
Roshini Claire Anthony, 21 Dec 2019

In acutely ill medical patients, asymptomatic proximal deep-vein thrombosis (ASxDVT), as assessed via compression ultrasonography, is associated with an elevated risk of all-cause mortality, according to a post hoc analysis of the MAGELLAN* trial presented at ASH 2019.

Tristan Manalac, 14 Dec 2019
Luspatercept promotes red blood cell (RBC) transfusion independence among low-risk myelodysplastic syndrome (MDS) patients, according to a longer-term analysis of the MEDALIST study presented at the recently concluded 61st Annual Meeting and Exposition of the American Society of Hematology (ASH 2019).

Pre-eclampsia linked to preclinical atherosclerosis in T1D women

19 Jan 2020

Previous pre-eclampsia (PE) is associated with increased preclinical carotid atherosclerosis in women with type 1 diabetes (T1D), reports a study.

One hundred twelve women without cardiovascular (CV) disease and who had their last pregnancy 5 years before were enrolled and categorized as follows: (1) T1D and previous PE (T1D+/PE+; n=28); (2) T1D without PE (T1D+/PE; n=28); (3) previous PE without T1D (T1D/PE+; n=28); and (4) controls (without T1D or PE; T1D/PE; n=28).

The authors matched the groups by age, several CV risk factors, and diabetes duration and retinopathy (in women with T1D). Standardized ultrasonography protocol was used to assess carotid intima-media thickness (IMT) and the presence of plaque (IMT 1.5 mm).

Of the participants (mean age, 44.9±7.8 years), 21.4 percent were active smokers and 14.3 percent had hypertension). Women in T1D groups (T1D+/PE+ and T1D+/PE) were more likely to present with hypertension (23.2 percent vs 5.4 percent; p<0.01) and be on statin treatment (37.5 percent vs 8.9; p<0.01), without differences in other CV risk factors. About a fifth (20.5 percent) of the participants had carotid plaques.

Multivariate models adjusted for age, statins and CV risk factors showed a similar impact of both T1D (odds ratio [OR], 5.45, 95 percent confidence interval [CI], 1.36–21.9) and PE (OR, 4.24, 95 percent CI, 1.04–17.3) on the presence of plaque.

An additive effect was observed when T1D and PE were combined, both in common carotid-IMT (T1D+/PE or T1D/PE+: β, 0.198; T1D+/PE+: β, 0.297) and in the presence of plaque (OR, 8.53, 95 percent CI, 1.07–68.2 and OR, 28.1, 95 percent CI, 2.67–296.4, respectively).

“Further studies are needed to ascertain its usefulness for stratifying risk in T1D women,” according to the authors.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Stephen Padilla, 11 Feb 2020
The inclusion of two proanthocyanidin (PA)-rich apples into normal diets improves cardiovascular disease (CVD) risk factors by reducing total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and intercellular cell adhesion molecule-1 (ICAM-1), as well as increasing microvascular vasodilation, in individuals with mildly elevated serum cholesterol concentrations, a recent study has shown.
Roshini Claire Anthony, 21 Dec 2019

In acutely ill medical patients, asymptomatic proximal deep-vein thrombosis (ASxDVT), as assessed via compression ultrasonography, is associated with an elevated risk of all-cause mortality, according to a post hoc analysis of the MAGELLAN* trial presented at ASH 2019.

Tristan Manalac, 14 Dec 2019
Luspatercept promotes red blood cell (RBC) transfusion independence among low-risk myelodysplastic syndrome (MDS) patients, according to a longer-term analysis of the MEDALIST study presented at the recently concluded 61st Annual Meeting and Exposition of the American Society of Hematology (ASH 2019).