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Pre-eclampsia leads to adverse respiratory outcomes in extremely premature neonates

16 Apr 2019

Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome (RDS) and severe bronchopulmonary dysplasia (BPD), according to a study.

Researchers examined a cohort of 1,218 infants born at 23–28 weeks of gestational age, among whom 23 percent were exposed to pre-eclampsia. Exposed infants, when compared with those who were not, were of a higher gestational age (26.2 vs 25.5 weeks; p<0.001) but weighed less (739 vs 830 g; p<0.001) at birth.

In the group of infants who were alive at the end of day 1 (n=1,190), severe RDS occurred with greater frequency in the pre-eclampsia group than in the nonexposed group. Logistic regression models showed that pre-eclampsia was associated with an elevated risk of incident severe RDS (odds ratio [OR], 2.4; 95 percent CI, 1.8–3.3). Analysis by generalized estimating equations (GEE), which controlled for correlation between siblings, confirmed the association (OR, 2.31; 1.59–3.34).

Among infants who were alive at 36 weeks postmenstrual age (n=1,033), significantly more infants in the pre-eclampsia group developed BPD and severe BPD than in the nonexposed group. Logistic regression revealed a relationship between the pregnancy disorder and increased risks of BPD (OR, 1.64; 1.12–2.40) and severe BPD (OR, 2.18; 1.45–3.28).

On GEE analysis, however, the association remained significant for severe BPD (OR, 2.17; 1.41–3.33) only.

The findings highlight the need to further explore the processes triggered by pre-eclampsia, as well as to develop strategies for early detection and treatment that could avert some of the harmful effects on foetal development and neonatal respiratory outcomes, according to researchers.

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Most Read Articles
6 days ago
The consumption of red and processed meats does not seem to affect the likelihood of symptom relapse among Crohn’s disease (CD) patients in relapse, reports a recent study.
Pearl Toh, 4 days ago
In addition to the known evils of maternal smoking during pregnancy on the son’s semen quality, prenatal exposure to paternal smoking can also be harmful, according to data from a large Danish National Birth Cohort (DNBC) presented at the ESHRE 2019 Meeting.
6 days ago
Treatment with metformin may improve whole-body and peripheral insulin resistance (IR) in youth who are overweight/obese with type 1 diabetes (T1D), according to a study.
4 days ago
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