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17 Apr 2019
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April 17 marks World Haemophilia Day, and this year’s theme is  “Reaching Out – The First Step to Care”. Adjunct Assoc Prof Joyce Lam Ching Mei, head of the Haematology Laboratory and Blood Bank and senior consultant from the Paediatric Haematology/Oncology Service at KK Women’s and Children’s Hospital, Singapore, speaks to Elaine Soliven on the importance of recognizing and managing bleeding disorders in primary care.
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Pre-eclampsia leads to adverse respiratory outcomes in extremely premature neonates

16 Apr 2019

Extremely premature neonates who have been exposed to pre-eclampsia in utero are at high risk of developing severe respiratory distress syndrome (RDS) and severe bronchopulmonary dysplasia (BPD), according to a study.

Researchers examined a cohort of 1,218 infants born at 23–28 weeks of gestational age, among whom 23 percent were exposed to pre-eclampsia. Exposed infants, when compared with those who were not, were of a higher gestational age (26.2 vs 25.5 weeks; p<0.001) but weighed less (739 vs 830 g; p<0.001) at birth.

In the group of infants who were alive at the end of day 1 (n=1,190), severe RDS occurred with greater frequency in the pre-eclampsia group than in the nonexposed group. Logistic regression models showed that pre-eclampsia was associated with an elevated risk of incident severe RDS (odds ratio [OR], 2.4; 95 percent CI, 1.8–3.3). Analysis by generalized estimating equations (GEE), which controlled for correlation between siblings, confirmed the association (OR, 2.31; 1.59–3.34).

Among infants who were alive at 36 weeks postmenstrual age (n=1,033), significantly more infants in the pre-eclampsia group developed BPD and severe BPD than in the nonexposed group. Logistic regression revealed a relationship between the pregnancy disorder and increased risks of BPD (OR, 1.64; 1.12–2.40) and severe BPD (OR, 2.18; 1.45–3.28).

On GEE analysis, however, the association remained significant for severe BPD (OR, 2.17; 1.41–3.33) only.

The findings highlight the need to further explore the processes triggered by pre-eclampsia, as well as to develop strategies for early detection and treatment that could avert some of the harmful effects on foetal development and neonatal respiratory outcomes, according to researchers.

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Most Read Articles
17 Apr 2019
A family history of testicular cancer (TC), carcinoma, mesothelioma, sarcoma, malignant melanoma and malignant neuroepithelial tumours appears to increase the risk of paediatric and young adults’ TC, suggests a recent study.
19 Jul 2016
Acute gastroenteritis (AGE) remains a significant contributor to paediatric disease burden across the world in the 21st century. Rehydration remains the mainstay of therapy, while pharmacotherapy may have adjunctive benefits. We seek to review the evolution in management strategies of paediatric AGE, in particular the child with viral AGE.
Joyce Lam Ching Mei, 28 Mar 2019
April 17 marks World Haemophilia Day, and this year’s theme is  “Reaching Out – The First Step to Care”. Adjunct Assoc Prof Joyce Lam Ching Mei, head of the Haematology Laboratory and Blood Bank and senior consultant from the Paediatric Haematology/Oncology Service at KK Women’s and Children’s Hospital, Singapore, speaks to Elaine Soliven on the importance of recognizing and managing bleeding disorders in primary care.
Stephen Padilla, 28 Feb 2018
The 2-year preventive oral health programme in Singapore has succeeded in lowering the presence of severe early childhood caries (SECC) among infants and toddlers, driven primarily by the implementation of targeted behaviour modifications, such as reducing the consumption of sweetened milk and increased use of fluoridated toothpaste, reports a study.