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Pre-eclampsia/eclampsia carries increased risk of noninfectious uveitis postdelivery

05 Nov 2018

Pre-eclampsia/eclampsia (PEE) represents a potential risk factor for developing noninfectious uveitis after giving birth, according to a study.

The study included 2,073 postdelivery women aged ≥20 years who were diagnosed with PEE and 8,292 non-PEE controls. Significantly more women with PEE than controls developed noninfectious uveitis over a follow-up of 5 years (0.7 percent vs 0.2 percent; p=0.001), yielding an incidence rate of 1.5 vs 0.5 per 1,000 person-years, respectively.

Of those with PEE who developed the intraocular inflammatory condition, the mean age at PEE was 30.9 years and the mean interval from PEE diagnosis to noninfectious uveitis occurrence was 1.9 years. The majority (79 percent) had anterior uveitis.

Multivariate Cox proportional hazards model revealed a significant increase in the cumulative incidence of noninfectious uveitis among women with PEE (p=0.001). The risk of the occurrence of the intraocular inflammatory condition was about threefold higher in the PEE vs control group (adjusted hazard ratio, 2.96; 95 percent CI, 1.48–5.92; p=0.002).

The present data raise awareness that a history of PEE should be taken into account when women develop noninfectious uveitis, researchers said.

There are several limitations to the study, including those inherent to its retrospective design. Specifically, the clinical course, severity and manifestations of PEE and the intraocular condition could hardly be observed and accurately evaluated. Also, there is a lack of comparison with women without delivery, and it was difficult to differentiate nulliparous or multiparous women due to an inability to trace records of delivery.

Larger prospective clinical and laboratory investigations are therefore warranted to elucidate the causal relationship between PEE and noninfectious uveitis, researchers added.

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Most Read Articles
09 Jan 2019
Despite comparable efficacies, triamcinolone injections appear to be slightly superior over 5-fluorouracil injections for inducing keloid remission, a recent trial has found.
Jairia Dela Cruz, 6 days ago
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
Tristan Manalac, 6 days ago
Less than 15 percent of Singaporean adolescents get the recommended 8–10 hours of sleep on a school night, reports a recent study, noting that such short sleep duration is linked to symptoms of depression, overweight or obesity, and poorer self-rated health.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.