Pre-eclampsia/eclampsia carries increased risk of noninfectious uveitis postdelivery
Pre-eclampsia/eclampsia (PEE) represents a potential risk factor for developing noninfectious uveitis after giving birth, according to a study.
The study included 2,073 postdelivery women aged ≥20 years who were diagnosed with PEE and 8,292 non-PEE controls. Significantly more women with PEE than controls developed noninfectious uveitis over a follow-up of 5 years (0.7 percent vs 0.2 percent; p=0.001), yielding an incidence rate of 1.5 vs 0.5 per 1,000 person-years, respectively.
Of those with PEE who developed the intraocular inflammatory condition, the mean age at PEE was 30.9 years and the mean interval from PEE diagnosis to noninfectious uveitis occurrence was 1.9 years. The majority (79 percent) had anterior uveitis.
Multivariate Cox proportional hazards model revealed a significant increase in the cumulative incidence of noninfectious uveitis among women with PEE (p=0.001). The risk of the occurrence of the intraocular inflammatory condition was about threefold higher in the PEE vs control group (adjusted hazard ratio, 2.96; 95 percent CI, 1.48–5.92; p=0.002).
The present data raise awareness that a history of PEE should be taken into account when women develop noninfectious uveitis, researchers said.
There are several limitations to the study, including those inherent to its retrospective design. Specifically, the clinical course, severity and manifestations of PEE and the intraocular condition could hardly be observed and accurately evaluated. Also, there is a lack of comparison with women without delivery, and it was difficult to differentiate nulliparous or multiparous women due to an inability to trace records of delivery.
Larger prospective clinical and laboratory investigations are therefore warranted to elucidate the causal relationship between PEE and noninfectious uveitis, researchers added.