Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 16 Jan 2018
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
3 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
4 days ago
It appears that urgent repeat endoscopic retrograde cholangiopancreatography (ERCP) predicts failure of plastic stent treatment for biliary strictures (BS) following liver transplant, according to a study.

Pre-, postchemoradiation NLR predict prognosis in rectal cancer after curative TME

16 Mar 2017

Both pre- and postchemoradiation (CRT) neutrophil-lymphocyte ratio (NLR) have a prognostic value in patients with locally advanced rectal cancer who have received preoperative CRT and curative total mesorectal excision (TME), a new study shows.

The study included 110 patients with rectal cancer or rectal adenocarcinoma who received curative TME after preoperative CRT. Those with fevers, upper respiratory infections, urinary tract infections, rheumatoid diseases, metabolic syndrome or coronary artery disease were excluded.

Three-dimensional radiotherapy was performed simultaneously with chemotherapy with either intravenous 5-fluorouracil or oral capecitabine. NLR before preoperative CRT, during the weekly CRTs and 4 weeks after CRT was calculated.

Participants were grouped into three, according to pre- and post-CRT NLR values: ≤1.75 and ≤5.14, respectively (group A); >1.75 and ≤5.14, or ≤1.75 and >5.14, respectively (group B); and >1.75 and >5.14, respectively (group C). The respective median pre-CRT NLR in these groups were 1.22, 2.24 and 2.86 and median post-CRT NLR were 2.59, 3.13 and 5.86.

The overall 3-year disease-free survival rate was 73.1 percent; for groups A, B and C, these rates were 92.7, 73.0 and 47.3 percent, respectively (p=0.018). The 3-year locoregional recurrence-free survival (LRFS) for group A (96.2 percent) was significantly better compared to groups B (80.7 percent) and C (66.5 percent; p=0.017).

The 3-year distant metastasis-free survival for group C (51.7 percent) was significantly lower compared to groups A (92.7 percent) and B (76.4 percent; p=0.04). For the three groups, overall survival rates were 96.0, 85.5 and 59.8 percent, respectively (p=0.034).

Univariate analysis showed that pre-CRT NLR (p=0.040), post-CRT NLR (p=0.029), NLR group (p=0.027), perineural invasion (p=0.046), pathologic N stage (p=0.038) and pre-CRT carcinoembryonic antigen (CEA; p=0.021) were significantly associated with disease-free survival.

Multivariable analysis, on the other hand, showed that NLR group (p=0.028) and pre-CRT CEA (p=0.035) were the significant prognostic factors for disease-free survival.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 10 Jan 2018
A study finds no evidence that using pharmaceutical aids alone for smoking cessation helps improve the chances of successful quitting despite promising results in previous randomized trials and routine prescription of such drugs to help quit smoking.
Elvira Manzano, 16 Jan 2018
Cancer patients at risk for recurrent venous thromboembolism (VTE) are less likely to experience recurrence with rivaroxaban compared with dalteparin, the Select-D trial has shown, ushering in a new standard of care (SoC) for cancer-related VTE.
3 days ago
Rates of immunization particularly in a primary care setting can be improved by constant patient reminders and recall systems, a recent study has found.
4 days ago
It appears that urgent repeat endoscopic retrograde cholangiopancreatography (ERCP) predicts failure of plastic stent treatment for biliary strictures (BS) following liver transplant, according to a study.