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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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PPI use in type 2 diabetes may exacerbate hip fracture risk

06 Sep 2020

Type 2 diabetes mellitus (T2DM) patients taking proton pump inhibitors (PPIs) are at a higher risk of sustaining hip fractures, a recent study has found.

The retrospective, population-based analysis included 398,885 T2DM patients. After propensity score matching, 44,431 PPI users (mean age, 59.23±12.56 years; 57.2 percent male) were included in the analysis and compared to 177,364 non-users (mean age, 58.95±12.71 years; 57.2 percent male). The primary outcome was the development of hip fractures.

Over the follow-up period, 683 cases of hip fractures occurred in the PPI group, corresponding to an incidence rate of 1.54 percent. In comparison, 1,808 such episodes were reported in the non-PPI comparators, with a rate of 1.02 percent.

Cox proportional hazards regression models found that the use of PPIs significantly increased the risk of sustaining hip fractures (hazard ratio [HR], 1.41, 95 percent confidence interval [CI], 1.29–1.54; p<0.001). The statistical model was adjusted for comorbidities and medications. Sex also appeared to be an important factor, such that males saw a lower hip fracture risk than females (HR, 0.65, 95 percent CI, 0.60–0.70; p<0.001).

The researchers then grouped the PPI patients according to their defined daily dose (DDD): nonuse (<28 DDD; n=177,364), 28–65 DDD (n=14,985), 66–124 DDD (n=14,608), and >125 DDD (n=14,748). Compared with the lowest category of cumulative dose of PPI, all other DDDs conferred a higher risk of hip fractures, though without a trend indicative of a dose-response relationship.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.