Most Read Articles
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.
Jairia Dela Cruz, 2 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.

PPI not beneficial to patients receiving low-dose anticoagulation, aspirin

23 Aug 2019

Use of the proton pump inhibitor (PPI) pantoprazole does not cut the risk of upper gastrointestinal (GI) events but may reduce the risk of bleeding from gastroduodenal lesions in patients on low-dose anticoagulants and/or antiplatelet therapy, a study has shown.

Researchers conducted a three-by-two partial factorial double-blind trial, randomly assigning 17,598 individuals with stable cardiovascular disease and peripheral artery disease to one of the following treatment groups: pantoprazole 40 mg daily or placebo, as well as rivaroxaban 2.5 mg twice daily plus aspirin 100 mg once daily, rivaroxaban 5 mg twice daily, or aspirin 100 mg alone.

The primary outcome of time to first upper GI event (composite of overt bleeding, upper GI bleeding from a gastroduodenal lesion or of unknown origin, occult bleeding, symptomatic gastroduodenal ulcer or ≥5 erosions, upper GI obstruction, or perforation) did not significantly differ between the pantoprazole and placebo groups (102 of 8,791 events vs 116 of 8,807 events, respectively; hazard ratio [HR], 0.88, 95 percent CI, 0.67–1.15; p=0.35).

However, compared with placebo, the PPI was significantly associated with a decrease in bleeding from gastroduodenal lesion events (HR, 0.52, 0.28–0.94; p=0.03). The reduction proved to be greater when a posthoc definition of bleeding gastroduodenal lesion was applied (HR, 0.45, 0.27–0.74), although the number needed to treat was still high (n=982).

The present data suggest that routine use of PPI therapy is not warranted in patients initiating low-dose anticoagulants and/or antiplatelet therapy, according to the researchers. PPIs may be appropriate for patients at high risk of peptic ulcer disease.

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Most Read Articles
29 Jan 2020
Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes and its manifestations in individuals at high risk of cardiovascular disease, a study reports.
Stephen Padilla, 23 May 2019
A recent study has shown an association between regular use of glucosamine supplement to relieve osteoarthritis pain and lower risk of cardiovascular disease (CVD) events.
Pearl Toh, 10 Feb 2020
Contrary to popular concern, use of statins was not associated with a greater decline in memory or cognition in the elderly over 6 years, according to data from the observational MAS*.
Jairia Dela Cruz, 2 days ago
A wearable arrhythmia detection device, the AliveCor KardiaBand (KB), demonstrates moderate accuracy for diagnosing atrial fibrillation (AF) in comparison with a 12-lead electrocardiogram (ECG), as shown in a recent study. However, combining the automated device diagnosis with the electrophysiologists (EP) interpretation of unclassified readings improves overall accuracy.