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Poststroke anxiety linked to greater depressive symptoms, younger age

01 Oct 2019

Generalized anxiety symptoms commonly occur after stroke or transient ischaemic attack (TIA) and are associated with younger age and greater depressive symptoms, and these relationships persist even among patients without severe comorbid depressive symptoms, as reported in a recent study.

The study included 258 patients (median age, 65 years; 50 percent male) with stroke or TIA, none of whom were severely aphasic. All patients underwent complete neuropsychological testing and completed the Generalized Anxiety Disorder 7-item (GAD-7) and Center for Epidemiological Studies Depression (CES-D) scales.

Fifty-six patients (21.7 percent) had high GAD-7 scores (≥10), 65 (25.2 percent) had high CES-D scores (≥16), and 40 (15.5 percent) had both elevated generalized anxiety and depression scores.

Being at high risk of generalized anxiety after stroke/TIA was significantly predicted by younger age (odds ratio [OR], 0.96, 95 percent CI, 0.93–0.99; p=0.004) and greater depressive symptoms (OR, 1.20, 1.14–1.26; p≤0.001).

Furthermore, younger patients (≤50 years) were more likely to have both high depression and generalized anxiety scores compared with older patients (30 percent vs 12 percent; p=0.001).

Among patients without severe depressive symptoms (n=193; 75 percent), age and severity of depressive symptoms remained the only factors associated with the risk of generalized anxiety.

The findings highlight the importance of routine screening for depression and further evaluation of anxiety after stroke/TIA, given the frequency of young survivors presenting both generalized anxiety and depressive symptoms, researchers said.

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Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
2 days ago
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6 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
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