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01 Dec 2019
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Postprandial hyperglycaemia ups diabetic retinopathy risk

17 Dec 2019

Postprandial hyperglycaemia during clinical visits may predict diabetic retinopathy (DR) among patients with type 2 diabetes (T2D), a new study has shown.

Researchers performed a retrospective cohort analysis of 323 participants with 1–2-hour postbreakfast mean blood glucose (1–2h-PBBG) measurements and 406 participants with the same data 1–2 hours postlunch (1–2h-PLBG); another group of 487 patients with both measurements (1–2h-PBLBG) was also included. The endpoint was mild-to-moderate nonproliferative DR.

In the group with both postbreakfast and postlunch blood glucose measurements, 145 patients developed DR over a median follow-up of 6.9 years. Those who had had T2D for a longer time (p=0.0001), had higher body mass index (BMI; p=0.014) and had a higher mean 1–2h-PBLBG level (p<0.0001) were significantly more likely to develop the complication.

The same was true for the 1–2h-PBBG group, where 92 patients developed DR over a median follow-up of 7.5 years. An elevated mean 1–2h-PBBG concentration (p<0.0001), greater BMI (p=0.04) and longer diabetes duration (p=0.014) all significantly increased the risk of DR.

Postprandial glucose was likewise a significant risk factor for DR in the 1–2h-PLBG group (p=0.0005), along with T2D duration (p=0.002) and glycated haemoglobin (HbA1c) level (p<0.0001). In this group, 126 patients developed DR over the 6.7-year median follow-up.

The present study found that “even with well-controlled HbA1c levels, correcting postprandial hyperglycaemia is important for preventing DR, especially in middle-aged adults with T2D,” said the researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
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Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.