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Stephen Padilla, 12 Feb 2020
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Postprandial hyperglycaemia ups diabetic retinopathy risk

17 Dec 2019

Postprandial hyperglycaemia during clinical visits may predict diabetic retinopathy (DR) among patients with type 2 diabetes (T2D), a new study has shown.

Researchers performed a retrospective cohort analysis of 323 participants with 1–2-hour postbreakfast mean blood glucose (1–2h-PBBG) measurements and 406 participants with the same data 1–2 hours postlunch (1–2h-PLBG); another group of 487 patients with both measurements (1–2h-PBLBG) was also included. The endpoint was mild-to-moderate nonproliferative DR.

In the group with both postbreakfast and postlunch blood glucose measurements, 145 patients developed DR over a median follow-up of 6.9 years. Those who had had T2D for a longer time (p=0.0001), had higher body mass index (BMI; p=0.014) and had a higher mean 1–2h-PBLBG level (p<0.0001) were significantly more likely to develop the complication.

The same was true for the 1–2h-PBBG group, where 92 patients developed DR over a median follow-up of 7.5 years. An elevated mean 1–2h-PBBG concentration (p<0.0001), greater BMI (p=0.04) and longer diabetes duration (p=0.014) all significantly increased the risk of DR.

Postprandial glucose was likewise a significant risk factor for DR in the 1–2h-PLBG group (p=0.0005), along with T2D duration (p=0.002) and glycated haemoglobin (HbA1c) level (p<0.0001). In this group, 126 patients developed DR over the 6.7-year median follow-up.

The present study found that “even with well-controlled HbA1c levels, correcting postprandial hyperglycaemia is important for preventing DR, especially in middle-aged adults with T2D,” said the researchers.

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Most Read Articles
Stephen Padilla, 12 Feb 2020
Increased coffee consumption appears to lower the risk of colon adenoma, results of a meta-analysis have shown. However, this association should be carefully considered due to latent confusion and different exposure classification.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.