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Postprandial hyperglycaemia ups diabetic retinopathy risk

17 Dec 2019

Postprandial hyperglycaemia during clinical visits may predict diabetic retinopathy (DR) among patients with type 2 diabetes (T2D), a new study has shown.

Researchers performed a retrospective cohort analysis of 323 participants with 1–2-hour postbreakfast mean blood glucose (1–2h-PBBG) measurements and 406 participants with the same data 1–2 hours postlunch (1–2h-PLBG); another group of 487 patients with both measurements (1–2h-PBLBG) was also included. The endpoint was mild-to-moderate nonproliferative DR.

In the group with both postbreakfast and postlunch blood glucose measurements, 145 patients developed DR over a median follow-up of 6.9 years. Those who had had T2D for a longer time (p=0.0001), had higher body mass index (BMI; p=0.014) and had a higher mean 1–2h-PBLBG level (p<0.0001) were significantly more likely to develop the complication.

The same was true for the 1–2h-PBBG group, where 92 patients developed DR over a median follow-up of 7.5 years. An elevated mean 1–2h-PBBG concentration (p<0.0001), greater BMI (p=0.04) and longer diabetes duration (p=0.014) all significantly increased the risk of DR.

Postprandial glucose was likewise a significant risk factor for DR in the 1–2h-PLBG group (p=0.0005), along with T2D duration (p=0.002) and glycated haemoglobin (HbA1c) level (p<0.0001). In this group, 126 patients developed DR over the 6.7-year median follow-up.

The present study found that “even with well-controlled HbA1c levels, correcting postprandial hyperglycaemia is important for preventing DR, especially in middle-aged adults with T2D,” said the researchers.

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Most Read Articles
6 days ago
Chronic pancreatitis patients taking antioxidants (AO) supplementation show a sustained increase in blood levels of AO, but no additional benefit is seen on endocrine and exocrine functions, markers of fibrosis, oxidative stress (OS) and inflammation, nutritional status, pain, and quality of life (QOL) when compared with those on placebo, according to a study.
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