Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Postnatal dexamethasone exposure compromises childhood lung function in preemies

12 Jul 2018
The Kangaroo Mother Care (KMC) idea, which originated amid grinding poverty, may be a cheaper and better option than incubators in saving premature babies.

In very premature infants, postnatal exposure to dexamethasone while in the neonatal unit appears to reduce mean lung function at school age, according to a recent study.

Researchers conducted a follow-up study on 179 children who had entered into a randomized trial of two neonatal ventilation methods. Lung function outcomes included forced expiratory volume in 1 second (FEV1), peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory flow at 75 percent (FEF75), 50 percent (FEF50), 25 percent (FEF25) and 25–75 percent (FEF25–75) of the vital capacity.

At least one course of dexamethasone was reported in 28 percent (n=50) of participants, while the remaining had no exposure.

Adjusted multiple regression analysis showed that there were significant differences in favour of the unexposed children in terms of FEF75 (difference, –0.53; 95 percent CI, –0.85 to –0.21; p=0.002), FEF50 (difference, –0.74; –1.05 to –0.43; p<0.001), FEF25 (difference, –0.75; –1.07 to –0.44; p<0.001) and FEF25–75 (difference, –0.70; –1.08 to –0.33; p<0.001).

The same was true for FEV1 (difference, –0.87; –1.24 to –0.51; p<0.001), FVC (difference, –0.38; –0.75 to –0.01; p=0.043), PEF (difference, –10.74; –16.06 to –5.41; p<0.001) and FEV1:FVC (difference, –1.43; –2.09 to –0.78; p<0.001).

The effect of dexamethasone exposure on lung function was confirmed when analysis was based on equivalent percentage of children with abnormal function. For instance, 21 percent vs 43 percent of the nonexposed vs dexamethasone-exposed children had abnormal FEF75 z scores, respectively.

Similar findings were reported for FEF50 (22 percent vs 57 percent), FEF25 (15 percent vs 47 percent), FEV1 (13 percent vs 42 percent) and FVC (8 percent vs 15 percent) z scores.

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Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.