Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.

Postdischarge worsening renal function strongly predicts adverse CV events

11 Sep 2017
Kidney failures and organ donors: Singapore

Postdischarge worsening renal function is common in patients with type 2 diabetes and acute coronary syndromes with normal or mildly depressed renal function, and a strong risk factor for adverse cardiovascular events, according to a recent study.

A total of 204 patients (7.34 percent) had worsening renal function. Over a median follow-up of 2 years, the estimated rates of death and hospital admission for heart failure per 100 person-years were 3.45 (95 percent CI, 2.46 to 6.36) for those with worsening renal function compared with 1.43 (1.14 to 1.79) for patients with stable renal function.

Adjusted analysis revealed that worsening renal function correlated with the composite endpoints of all-cause death and hospitalization for heart failure (hazard ratio, 2.65; 1.57 to 4.49; p<0.001).

In this study, researchers considered the placebo cohort of the AleCardio trial comparing aleglitazar with standard medical therapy among patients with type 2 diabetes mellitus and a recent acute coronary syndrome.

In total, 2,776 patients were included in the analysis. Excluded were those who had died or had been admitted to hospital for heart failure before the 6-month follow-up, as well as patients without complete renal function data.

Worsening renal function was defined as a >20-percent reduction in estimated glomerular filtration rate from discharge to 6 months or progression to macroalbuminuria. Cox regression analysis was used to determine the prognostic impact of 6-month renal deterioration on the composite of all-cause death and hospital admission for heart failure.

“Worsening renal function during hospitalization for an acute coronary syndrome is strongly predictive of in-hospital and long-term outcome,” researchers noted.

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Audrey Abella, 20 Jan 2017
Diabetes was not a risk factor for total knee replacement (TKR) due to severe knee osteoarthritis, a Singapore study found.