Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 3 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 4 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.

Post-treatment symptoms predict depression, anxiety in uveal melanoma survivors

16 Jul 2018

In survivors of uveal melanoma, worry about recurrent disease (WREC) and post-treatment symptoms appear to contribute to long-term anxiety and depression, according to a recent study.

The analysis included 261 uveal melanoma survivors, of whom 26.8 percent (n=70) and 10.1 percent (n=26) had anxiety and depression at 6 months, respectively. The corresponding rates of anxiety and depression at 12 months were 25.7 percent (n=67) and 11.5 percent (n=30). At 24 months, the rates were 22.6 percent (n=59) and 11.5 percent (n=30), respectively.

Ocular irritation (odds ratio [OR], 1.23; 95 percent CI, 1.04–1.45; p<0.05), headaches (OR, 1.77.; 1.07–2.95; p<0.05) and functional problems (OR, 1.12; 1,00–1.25; p<0.05) at 6 months, and WREC at 12 months (OR, 1.34; 1.04–1.73; p<0.05) were significant predictors of anxiety development at 24 months.

In comparison, headaches (OR, 2.32; 1.10–4.92; p<0.05) and functional problems (OR, 1.16; 0.91–1.34; p<0.05) at 6 months were significant predictors of depression at 24 months.

The presence of WREC at 12 months mediated the predictive value for anxiety of the symptoms and functional problems at 6 months. No such predictive effects were observed for chromosome 3 status.

“[T]he focus of attention during follow-up should be on preparing patients to better understand and cope with symptoms and functional problems,” said researchers, noting that patients who report concerns about symptoms and functional problems should be monitored for psychological distress.

In addition, informing patients that symptoms do not necessarily lead to future disease may also help avoid psychological problems.

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Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 3 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

6 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Tristan Manalac, 4 days ago
The risk of complicated appendicitis is lower in children with IgE-mediated allergy, according to a recent study.