Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum. 

Possible new biomarkers for early prediction of spontaneous preterm birth

16 May 2017
Specific miRNA expression profiles have been identified that may enable noninvasive, early prediction of spontaneous preterm birth. If confirmed, such biomarkers could improve infant outcomes by facilitating the identification of women who may benefit from novel and existing therapies aimed at preventing such events.

In the nested, case-control pilot study, researchers used a miRNA array to analyse plasma samples taken from 24 healthy women in their first pregnancy at 20 weeks of gestation who were participants in the New Zealand Cohort of the Screening for Pregnancy End-points (SCOPE) study, and who delivered at term (n=12, controls) or experienced a spontaneous preterm birth at 28–32 weeks (n=12, cases).

Specific miRNA expression profiles that were able to differentiate between cases and controls were identified: miR302B, miR1253, and a cluster of miR548 miRNAs were underexpressed, and miR223 was elevated, among the women with a spontaneous preterm birth compared with the controls.

The researchers suggest that these miRNAs may be attractive candidates as noninvasive biomarkers for early prediction of spontaneous preterm birth, but further larger studies are required to investigate their clinical utility.
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Most Read Articles
KY Leung, 01 Feb 2014

Group B Streptococcus (GBS) is the commonest cause of severe early-onset neonatal infection, which is associated with a high rate of morbidity and mortality (5–10%).1-3 About half of GBS meningitis will be complicated by neurodevelopment impairment. Because the early-onset disease develops shortly and rapidly after birth, there has been little improvement in the disease treatment, and the focus thus lies in disease prevention.

Jairia Dela Cruz, 23 Oct 2017
Evacuation proctography, magnetic resonance imaging, and transperineal and endovaginal ultrasonography demonstrate similar diagnostic test accuracy for posterior pelvic floor disorders in women with obstructed defecation syndrome, a recent study has shown.
Dr. Joseph Delano Fule Robles, 14 Oct 2016

Results of a recent clinical trial showed that treatment with niraparib, a poly ADP ribose polymerase (PARP) inhibitor,  improved progression-free survival (PFS) by more than 15 months in patients with recurrent ovarian cancer responding to platinum.