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Positive outcomes seen in prostatectomy-treated younger men with prostate cancer

14 Jul 2017

Additional evidence suggests that younger men with prostate cancer who are treated with radical prostatectomy mostly have favourable disease characteristics and outcomes.

Researchers evaluated the histopathological features and associated clinical behaviour of prostate cancer in a cohort of younger men (n=171; median age 43 years; range, 38 to 49 years) treated with radical prostatectomy at an academic institution between 2001 and 2015. A comprehensive pathology review was performed.

The authors collected clinical and follow-up data from a prospectively maintained institutional database.

Forty-two percent of the tumours were Gleason score 3+3 and 45 percent were 3+4. On the other hand, 10.5, 0.5 and 1.0 percent of tumours were Gleason score 4+3, 4+4 and 4+5, respectively.

There were 11 cases (6 percent) of mucinous carcinoma (>25 percent extracellular mucin), an uncommon histological variant which comprises 0.2 percent of prostate cancers. Furthermore, 21 cases (12 percent) of acinar adenocarcinoma had a <25 percent mucinous component.

A total of 156 men (91 percent) had available follow-up data. Twelve patients (19 percent) developed biochemical recurrence, but there was no documented postoperative metastasis or death from disease in the cohort.

All cases of mucinous carcinoma were likely to have favourable clinicopathological characteristics.

“While the histopathological features in our series were generally comparable to those of older onset carcinoma, our cohort was enriched for tumours with a mucinous phenotype,” researchers said. “Correlation with molecular-genetic analysis in this subset of tumors may be valuable.”

Prostate cancer is mostly a disease of older men, but younger men with the disease remain a significant clinical subgroup that has not been sufficiently explored, researchers noted.

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Most Read Articles
15 Nov 2017
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.
Yesterday
Long-term use of benzodiazepines is independently associated with lower diastolic and systolic blood pressure in ambulatory blood pressure monitoring (ABPM) among older but not younger patients, a study has found.
3 days ago
There appears to be a paradox in the context of smoking and the risk of psoriatic arthritis (PsA), such that current smoking increases the risk of developing PsA in the general population but protects against the same risk among patients with psoriasis, according to a study.
4 days ago
Moderate increases in physical activity levels may translate to significant reductions in both fasting glucose and HbA1c, a study has found.