Most Read Articles
Pearl Toh, 15 Feb 2019
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
30 Nov 2018
Poor adherence to statin therapy is leaving many patients with dyslipidaemia at high risk of potentially life-threatening cardiovascular events. Statins are the current standard of care for reducing the risk of cardiovascular disease in these patients and for improving life expectancy, with possible economic benefits for healthcare systems too. However, many patients with dyslipidaemia are not achieving or maintaining treatment targets because they fail to stick to their prescribed statin therapy. An article co-authored by lipidologist Peter Lansberg, and published in Vascular Health and Risk Management, considers this issue and reviews approaches to overcome non-adherence.

Poor preconceptional CV health tied to preterm birth, SGA in women with SLE

04 Feb 2019

An association exists between poor/intermediate preconceptional cardiovascular (CV) health and pregnancy outcomes of preterm birth and small for gestational age (SGA) infants among women with systemic lupus erythematosus (SLE), suggests a recent study.

A total of 309 live births were analysed, with 95 being preterm (31 percent). Eighteen percent of the 293 pregnancies with birth weight data were SGA. Ideal body mass index (BMI) was reported in 56 percent of pregnancies, while total cholesterol and blood pressure (BP) were reported in 85 percent and 51 percent, respectively.

When adjusted for race and prednisone use, an association was found between intermediate BMI and lower odds of SGA (odds ratio [OR], 0.26; 95 percent CI, 0.11–0.63). Poor/intermediate total cholesterol correlated with an increased risk of preterm birth (OR, 2.21; 1.06–4.62), while poor/intermediate BP correlated with lower gestational age at birth (β −0.96; –1.62 to –0.29).

“Efforts to maintain BMI, total cholesterol and BP within the recommended ideal range prior to pregnancy is important to improve pregnancy outcomes in women with SLE,” the authors said.

This study enrolled patients in the Hopkins Lupus Pregnancy Cohort to assess the effects of preconceptional CV health on pregnancy outcomes in women with SLE. CV health (ideal, intermediate or poor) based on the American Heart Association definitions was determined using BMI, total cholesterol and BP in the most recent clinic visit prior to conception or first trimester.

Measured outcomes were preterm birth, gestational age at birth and SGA. The authors used multivariable linear and logistic regression models with generalized estimating equations to examine the association of each CV health factor and outcome.

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Most Read Articles
Pearl Toh, 15 Feb 2019
A latest study at ISC 2019 shows that even patients with large-core stroke damage can have a good outcome after mechanical clot removal with endovascular thrombectomy (EVT), depending on the size of the infarct and time lapses between stroke onset and treatment.
30 Nov 2018
Poor adherence to statin therapy is leaving many patients with dyslipidaemia at high risk of potentially life-threatening cardiovascular events. Statins are the current standard of care for reducing the risk of cardiovascular disease in these patients and for improving life expectancy, with possible economic benefits for healthcare systems too. However, many patients with dyslipidaemia are not achieving or maintaining treatment targets because they fail to stick to their prescribed statin therapy. An article co-authored by lipidologist Peter Lansberg, and published in Vascular Health and Risk Management, considers this issue and reviews approaches to overcome non-adherence.